UniProt Accession

 ZO2_MOUSE; Q9Z0U1; Q8K210 

Genbank Protein ID

 AF113005; BC034677; BC039924 

Genbank Nucleotide ID

 AAD19964.1; AAH34677.1; AAH39924.1 

Protein Name

 Tight junction protein ZO-2 

Protein Synonyms/Alias

 Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2 

Gene Name

 Tjp2 

Gene Synonyms/Alias

 Zo2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
294	GVLLTKSKANEEYGL	ubiquitination	[1]
320	TRTGLATKDGNLHEG	ubiquitination	[1]
414	DYHSSTEKLKERPSS	ubiquitination	[1]
440	GATPTPFKSTGDITA	ubiquitination	[1]
621	VDTLYDGKLGHWLAV	ubiquitination	[1]
751	PKDAGSEKSSGVVRL	ubiquitination	[1]
993	EDSFDYSKSNLPATA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a role in tight junctions and adherens junctions. 

Sequence Annotation

 DOMAIN 10 97 PDZ 1.
 DOMAIN 287 365 PDZ 2.
 DOMAIN 489 570 PDZ 3.
 DOMAIN 584 649 SH3.
 DOMAIN 660 858 Guanylate kinase-like.
 REGION 1165 1167 Interaction with SCRIB (By similarity).
 MOD_RES 107 107 Phosphoserine.
 MOD_RES 130 130 Phosphoserine (By similarity).
 MOD_RES 145 145 Phosphoserine (By similarity).
 MOD_RES 147 147 Phosphoserine (By similarity).
 MOD_RES 173 173 Phosphoserine (By similarity).
 MOD_RES 194 194 Phosphoserine (By similarity).
 MOD_RES 238 238 Phosphotyrosine.
 MOD_RES 239 239 Phosphoserine.
 MOD_RES 263 263 Phosphoserine.
 MOD_RES 265 265 Phosphoserine.
 MOD_RES 267 267 Phosphoserine.
 MOD_RES 380 380 Phosphoserine (By similarity).
 MOD_RES 410 410 Phosphoserine (By similarity).
 MOD_RES 435 435 Phosphothreonine (By similarity).
 MOD_RES 684 684 Phosphoserine (By similarity).
 MOD_RES 902 902 Phosphoserine (By similarity).
 MOD_RES 907 907 Phosphothreonine (By similarity).
 MOD_RES 915 915 Phosphothreonine (By similarity).
 MOD_RES 948 948 Phosphoserine (By similarity).
 MOD_RES 960 960 Phosphoserine (By similarity).
 MOD_RES 968 968 Phosphoserine.
 MOD_RES 988 988 Phosphoserine.
 MOD_RES 1044 1044 Phosphoserine (By similarity).
 MOD_RES 1095 1095 Phosphotyrosine.
 MOD_RES 1124 1124 Phosphoserine (By similarity).
 MOD_RES 1136 1136 Phosphoserine (By similarity).  

Keyword

 3D-structure; Cell junction; Cell membrane; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Tight junction. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1167 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IDA:MGI.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell. 

Interpro

 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR011511; SH3_2.
 IPR001452; SH3_domain.
 IPR005417; ZonOcculdens.
 IPR005419; ZonOcculS2. 

Pfam

 PF00625; Guanylate_kin
 PF00595; PDZ
 PF07653; SH3_2 

SMART

 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 

PROSITE

 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3 

PRINTS

 PR01597; ZONOCCLUDNS.
 PR01599; ZONOCCLUDNS2.