CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030364
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin, heavy polypeptide 7, cardiac muscle, beta 
Protein Synonyms/Alias
  
Gene Name
 Myh7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
43DVFVPDDKEEFVKAKubiquitination[1]
58IVSREGGKVTAETENubiquitination[1]
67TAETENGKTVTVKEDubiquitination[1]
83VMQQNPPKFDKIEDMubiquitination[1]
213KKDQTPGKGTLEDQIubiquitination[2]
234LEAFGNAKTVRNDNSubiquitination[1]
397LNSADLLKGLCHPRVubiquitination[1]
640KGKGKAKKGSSFQTVubiquitination[1]
657LHRENLNKLMTNLRSubiquitination[1]
910ERCDQLIKNKIQLEAubiquitination[1]
912CDQLIKNKIQLEAKVubiquitination[1]
942ELTAKKRKLEDECSEubiquitination[1]
963DLELTLAKVEKEKHAubiquitination[1]
966LTLAKVEKEKHATENubiquitination[1]
997VKLTKEKKALQEAHQubiquitination[1]
1016DLQAEEDKVNTLTKAubiquitination[1]
1026TLTKAKVKLEQQVDDubiquitination[1]
1042EGSLEQEKKVRMDLEubiquitination[1]
1106ALGSQLQKKLKELQAubiquitination[1]
1107LGSQLQKKLKELQARubiquitination[1]
1109SQLQKKLKELQARIEubiquitination[1]
1279DLTSQRAKLQTENGEubiquitination[1]
1305ISQLTRGKLTYTQQLubiquitination[1]
1326LEEEVKAKNALAHALubiquitination[1]
1503ETFKRENKNLQEEISubiquitination[1]
1531HELEKIRKQLEAEKLubiquitination[2]
1537RKQLEAEKLELQSALubiquitination[2]
1557SLEHEEGKILRAQLEubiquitination[1]
1644AEAQKQVKSLQSLLKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] A proteomics approach to identify the ubiquitinated proteins in mouse heart.
 Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ.
 Biochem Biophys Res Commun. 2007 Jun 8;357(3):731-6. [PMID: 17451654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Motor protein; Myosin; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1935 AA 
Protein Sequence
MADAEMAAFG AAAPFLRKSE KERLEAQTRP FDLKKDVFVP DDKEEFVKAK IVSREGGKVT 60
AETENGKTVT VKEDQVMQQN PPKFDKIEDM AMLTFLHEPA VLYNLKERYA SWMIYTYSGL 120
FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA PPHIFSISDN AYQYMLTDRE NQSILITGES 180
GAGKTVNTKR VIQYFAVIAA IGDRSKKDQT PGKGTLEDQI IQANPALEAF GNAKTVRNDN 240
SSRFGKFIRI HFGATGKLAS ADIETYLLEK SRVIFQLKAE RDYHIFYQIL SNKKPELLDM 300
LLITNNPYDY AFISQGETTV ASIDDSEELM ATDSAFDVLG FTPEEKNSIY KLTGAIMHFG 360
NMKFKQKQRE EQAEPDGTEE ADKSAYLMGL NSADLLKGLC HPRVKVGNEY VTKGQNVQQV 420
SYAIGALAKS VYEKMFNWMV TRINATLETK QPRQYFIGVL DIAGFEIFDF NSFEQLCINF 480
TNEKLQQFFN HHMFVLEQEE YKKEGIEWTF IDFGMDLQAC IDLIEKPMGI MSILEEECMF 540
PKATDMTFKA KLYDNHLGKS NNFQKPRNVK GKQEAHFSLV HYAGTVDYNI LGWLQKNKDP 600
LNETVVGLYQ KSSLKLLSNL FANYAGADAP ADKGKGKAKK GSSFQTVSAL HRENLNKLMT 660
NLRSTHPHFV RCIIPNETKS PGVMDNPLVM HQLRCNGVLE GIRICRKGFP NRILYGDFRQ 720
RYRILNPAAI PEGQFIDSRK GAEKLLGSLD IDHNQYKFGH TKVFFKAGLL GLLEEMRDER 780
LSRIITRIQA QSRGVLSRME FKKLLERRDS LLIIQWNIRA FMGVKNWPWM KLYFKIKPLL 840
KSAETEKEMA TMKEEFGRVK DALEKSEARR KELEEKMVSL LQEKNDLQLQ VQAEQDNLAD 900
AEERCDQLIK NKIQLEAKVK EMTERLEDEE EMNAELTAKK RKLEDECSEL KRDIDDLELT 960
LAKVEKEKHA TENKVKNLTE EMAGLDEIIV KLTKEKKALQ EAHQQALDDL QAEEDKVNTL 1020
TKAKVKLEQQ VDDLEGSLEQ EKKVRMDLER AKRKLEGDLK LTQESIMDLE NDKQQLDERL 1080
KKKDFELNAL NARIEDEQAL GSQLQKKLKE LQARIEELEE ELEAERTARA KVEKLRSDLS 1140
RELEEISERL EEAGGATSVQ IEMNKKREAE FQKMRRDLEE ATLQHEATAA ALRKKHADSV 1200
AELGEQIDNL QRVKQKLEKE KSEFKLELDD VTSNMEQIIK AKANLEKMCR TLEDQMNEHR 1260
SKAEETQRSV NDLTSQRAKL QTENGELSRQ LDEKEALISQ LTRGKLTYTQ QLEDLKRQLE 1320
EEVKAKNALA HALQSARHDC DLLREQYEEE TEAKAELQRV LSKANSEVAQ WRTKYETDAI 1380
QRTEELEEAK KKLAQRLQDA EEAVEAVNAK CSSLEKTKHR LQNEIEDLMV DVERSNAAAA 1440
ALDKKQRNFD KILAEWKQKY EESQSELESS QKEARSLSTE LFKLKNAYEE SLEHLETFKR 1500
ENKNLQEEIS DLTEQLGSTG KSIHELEKIR KQLEAEKLEL QSALEEAEAS LEHEEGKILR 1560
AQLEFNQIKA EIERKLAEKD EEMEQAKRNH LRMVDSLQTS LDAETRSRNE ALRVKKKMEG 1620
DLNEMEIQLS HANRMAAEAQ KQVKSLQSLL KDTQIQLDDA VRANDDLKEN IAIVERRNNL 1680
LQAELEELRA VVEQTERSRK LAEQELIETS ERVQLLHSQN TSLINQKKKM DADLSQLQTE 1740
VEEAVQECRN AEEKAKKAIT DAAMMAEELK KEQDTSAHLE RMKKNMEQTI KDLQHRLDEA 1800
EQIALKGGKK QLQKLEARVR ELENELEAEQ KRNAESVKGM RKSERRIKEL TYQTEEDRKN 1860
LLRLQDLVDK LQLKVKAYKR QAEEAEEQAN TNLSKFRKVQ HELDEAEERA DIAESQVNKL 1920
RAKSRDIGAK GLNEE 1935 
Gene Ontology
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0016459; C:myosin complex; IDA:MGI.
 GO:0032982; C:myosin filament; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0001725; C:stress fiber; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0030898; F:actin-dependent ATPase activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0008307; F:structural constituent of muscle; IEA:Compara.
 GO:0007512; P:adult heart development; IEA:Compara.
 GO:0030049; P:muscle filament sliding; IEA:Compara.
 GO:0002027; P:regulation of heart rate; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.