CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016309
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein MEX3D 
Protein Synonyms/Alias
 RING finger and KH domain-containing protein 1; RING finger protein 193; TINO 
Gene Name
 MEX3D 
Gene Synonyms/Alias
 KIAA2031; RKHD1; RNF193 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
256IIRATRSKAGGLPGAubiquitination[1]
314IVTPGRDKEPVFAVTubiquitination[1]
586GASENSRKPPSASSAubiquitination[1]
631CAVRICGKSEPECPAubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 RNA binding protein, may be involved in post- transcriptional regulatory mechanisms (By similarity). 
Sequence Annotation
 DOMAIN 179 240 KH 1.
 DOMAIN 273 334 KH 2.
 ZN_FING 600 640 RING-type.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 651 AA 
Protein Sequence
MPSSLGQPDG GGGGGGGGGG VGAAGEDPGP GPAPPPEGAQ EAAPAPRPPP EPDDAAAALR 60
LALDQLSALG LGGAGDTDEE GAAGDGAAAA GGADGGAAPE PVPPDGPEAG APPTLAPAVA 120
PGSLPLLDPN ASPPPPPPPR PSPPDVFAGF APHPAALGPP TLLADQMSVI GSRKKSVNMT 180
ECVPVPSSEH VAEIVGRQGC KIKALRAKTN TYIKTPVRGE EPVFIVTGRK EDVEMAKREI 240
LSAAEHFSII RATRSKAGGL PGAAQGPPNL PGQTTIQVRV PYRVVGLVVG PKGATIKRIQ 300
QRTHTYIVTP GRDKEPVFAV TGMPENVDRA REEIEAHITL RTGAFTDAGP DSDFHANGTD 360
VCLDLLGAAA SLWAKTPNQG RRPPTATAGL RGDTALGAPS APEAFYAGSR GGPSVPDPGP 420
ASPYSGSGNG GFAFGAEGPG APVGTAAPDD CDFGFDFDFL ALDLTVPAAA TIWAPFERAA 480
PLPAFSGCST VNGAPGPPAA GARRSSGAGT PRHSPTLPEP GGLRLELPLS RRGAPDPVGA 540
LSWRPPQGPV SFPGGAAFST ATSLPSSPAA AACAPLDSGA SENSRKPPSA SSAPALAREC 600
VVCAEGEVMA ALVPCGHNLF CMDCAVRICG KSEPECPACR TPATQAIHIF S 651 
Gene Ontology
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
 GO:0017091; F:AU-rich element binding; IDA:BHF-UCL.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0061157; P:mRNA destabilization; NAS:BHF-UCL.
 GO:0010609; P:mRNA localization resulting in posttranscriptional regulation of gene expression; NAS:BHF-UCL. 
Interpro
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00013; KH_1 
SMART
 SM00322; KH
 SM00184; RING 
PROSITE
 PS50084; KH_TYPE_1
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS