CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008095
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CD97 antigen 
Protein Synonyms/Alias
 Leukocyte antigen CD97; CD97; CD97 antigen subunit alpha; CD97 antigen subunit beta 
Gene Name
 CD97 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
730SEINPDMKKLKKARAubiquitination[1, 2]
809CLVAGGSKYSEFTSTubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity). 
Sequence Annotation
 DOMAIN 22 63 EGF-like 1.
 DOMAIN 64 115 EGF-like 2; calcium-binding (Potential).
 DOMAIN 116 159 EGF-like 3; calcium-binding (Potential).
 DOMAIN 160 208 EGF-like 4; calcium-binding (Potential).
 DOMAIN 209 257 EGF-like 5; calcium-binding (Potential).
 DOMAIN 492 542 GPS.
 MOD_RES 831 831 Phosphoserine.
 MOD_RES 833 833 Phosphoserine.
 CARBOHYD 33 33 N-linked (GlcNAc...) (Potential).
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
 CARBOHYD 203 203 N-linked (GlcNAc...) (Potential).
 CARBOHYD 371 371 N-linked (GlcNAc...).
 CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
 CARBOHYD 413 413 N-linked (GlcNAc...) (Potential).
 CARBOHYD 453 453 N-linked (GlcNAc...).
 CARBOHYD 520 520 N-linked (GlcNAc...) (Potential).
 DISULFID 26 36 By similarity.
 DISULFID 30 42 By similarity.
 DISULFID 44 62 By similarity.
 DISULFID 68 82 By similarity.
 DISULFID 76 91 By similarity.
 DISULFID 93 114 By similarity.
 DISULFID 120 133 By similarity.
 DISULFID 127 142 By similarity.
 DISULFID 144 158 By similarity.
 DISULFID 164 177 By similarity.
 DISULFID 171 186 By similarity.
 DISULFID 188 207 By similarity.
 DISULFID 213 226 By similarity.
 DISULFID 220 235 By similarity.
 DISULFID 237 256 By similarity.  
Keyword
 Alternative splicing; Calcium; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; EGF-like domain; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 835 AA 
Protein Sequence
MGGRVFLAFC VWLTLPGAET QDSRGCARWC PQNSSCVNAT ACRCNPGFSS FSEIITTPTE 60
TCDDINECAT PSKVSCGKFS DCWNTEGSYD CVCSPGYEPV SGAKTFKNES ENTCQDVDEC 120
QQNPRLCKSY GTCVNTLGSY TCQCLPGFKF IPEDPKVCTD VNECTSGQNP CHSSTHCLNN 180
VGSYQCRCRP GWQPIPGSPN GPNNTVCEDV DECSSGQHQC DSSTVCFNTV GSYSCRCRPG 240
WKPRHGIPNN QKDTVCEDMT FSTWTPPPGV HSQTLSRFFD KVQDLGRDSK TSSAEVTIQN 300
VIKLVDELME APGDVEALAP PVRHLIATQL LSNLEDIMRI LAKSLPKGPF TYISPSNTEL 360
TLMIQERGDK NVTMGQSSAR MKLNWAVAAG AEDPGPAVAG ILSIQNMTTL LANASLNLHS 420
KKQAELEEIY ESSIRGVQLR RLSAVNSIFL SHNNTKELNS PILFAFSHLE SSDGEAGRDP 480
PAKDVMPGPR QELLCAFWKS DSDRGGHWAT EGCQVLGSKN GSTTCQCSHL SSFAILMAHY 540
DVEDWKLTLI TRVGLALSLF CLLLCILTFL LVRPIQGSRT TIHLHLCICL FVGSTIFLAG 600
IENEGGQVGL RCRLVAGLLH YCFLAAFCWM SLEGLELYFL VVRVFQGQGL STRWLCLIGY 660
GVPLLIVGVS AAIYSKGYGR PRYCWLDFEQ GFLWSFLGPV TFIILCNAVI FVTTVWKLTQ 720
KFSEINPDMK KLKKARALTI TAIAQLFLLG CTWVFGLFIF DDRSLVLTYV FTILNCLQGA 780
FLYLLHCLLN KKVREEYRKW ACLVAGGSKY SEFTSTTSGT GHNQTRALRA SESGI 835 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0006928; P:cellular component movement; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0006954; P:inflammatory response; TAS:ProtInc.
 GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. 
Interpro
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR017981; GPCR_2-like.
 IPR003056; GPCR_2_CD97.
 IPR000832; GPCR_2_secretin-like.
 IPR017983; GPCR_2_secretin-like_CS.
 IPR000203; GPS_dom. 
Pfam
 PF00002; 7tm_2
 PF07645; EGF_CA
 PF01825; GPS 
SMART
 SM00179; EGF_CA
 SM00303; GPS 
PROSITE
 PS00010; ASX_HYDROXYL
 PS50026; EGF_3
 PS01187; EGF_CA
 PS00650; G_PROTEIN_RECEP_F2_2
 PS50261; G_PROTEIN_RECEP_F2_4
 PS50221; GPS 
PRINTS
 PR01278; CD97PROTEIN.
 PR00249; GPCRSECRETIN.