CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024546
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoporin SEH1 
Protein Synonyms/Alias
 Nup107-160 subcomplex subunit SEH1 
Gene Name
 SEH1L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Bos taurus (Bovine) 
NCBI Taxa ID
 9913 
Lysine Modification
Position
Peptide
Type
References
96IVGESNDKLRGQSHWubiquitination[1]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (By similarity). 
Sequence Annotation
 REPEAT 10 49 WD 1.
 REPEAT 55 96 WD 2.
 REPEAT 111 152 WD 3.
 REPEAT 160 210 WD 4.
 REPEAT 217 258 WD 5.
 REPEAT 276 315 WD 6.  
Keyword
 Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Complete proteome; Kinetochore; Mitosis; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Repeat; Translocation; Transport; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGEWHCT ASWKTHSGSV 60
WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKLRGQ SHWVKRTTLV DSRTSVTDVK 120
FAPKHMGLML ATCSADGIVR IYEAPDVMNL SQWSLQHEIS CKLSCSCISW NPSSSRAHAP 180
MIAVGSDDSS PNAMAKVQIF EYNENTRKYA KAETLLTVTD PVHDIAFAPN LGRSFHILAI 240
ATKDVRIFTL KPVRKELTSS GGPTKFEIHI VAQFDNHNSQ VWRVSWNITG TVLASSGDDG 300
CVRLWKANYM DNWKCTGILK GNGSPVNGSS QQGNSNPSVG SNIPSLQNSL NGSSAGRKHS 360 
Gene Ontology
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0031080; C:nuclear pore outer ring; ISS:UniProtKB.
 GO:0051315; P:attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0006999; P:nuclear pore organization; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.