CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044772
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase SHPRH 
Protein Synonyms/Alias
 SNF2 histone linker PHD RING helicase, isoform CRA_a 
Gene Name
 SHPRH 
Gene Synonyms/Alias
 hCG_18061 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
830MVECPTVKAAEMAQRubiquitination[1, 2]
1020LLTSLQKKCGTECEEubiquitination[2]
1071EEHKGKLKTDSLQRLubiquitination[2]
1260LFTEYESKLFSNTVKubiquitination[3]
1395EVEQNRIKLLNDKAVubiquitination[2]
1400RIKLLNDKAVATSQLubiquitination[2]
1426NLEKSQDKTSGGVNPubiquitination[2]
1566FAQISRVKTFQENLSubiquitination[2, 3]
1576QENLSAFKRDPQINIubiquitination[3]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1687 AA 
Protein Sequence
MSSRRKRAPP VRVDEEKRQQ LHWNMHEDRR NEPIIISDDD EQPCPGSDTS SAHYIILSDS 60
LKEEVAHRDK KRCSKVVSFS KPIEKEETVG IFSPLSVKLN IVISPYHFDN SWKAFLGELT 120
LQLLPAQSLI ENFSERSITL MSSESSNQFL IYVHSKGEDV EKQKKEPMSI CDKGILVESS 180
FSGEMLEDLG WLQKKRRIKL YQKPEGNHII KVGIYLLEAG LAKLDFLSDA NSRMKKFNQL 240
MKKVMEKLHN SIIPDVLEED EDDPESEPEG QDIDELYHFV KQTHQQETQS IQVDVQHPAL 300
IPVLRPYQRE AVNWMLQQEC FRSSPATESA LHFLWREIVT SEGLKLYYNP YTGCIIREYP 360
NSGPQLLGGI LADEMGLGKT VEVLALILTH TRQDVKQDAL TLPEGKVVNY FIPSHYFGGK 420
LKKTEIQNIE FEPKEKVQCP PTRVMILTAV KEMNGKKGVS ILSIYKYVSS IYRYDVQRNR 480
SLLKRMLKCL IFEGLVKQIK GHGFSGTFTL GKNYKEEDIC DKTKKQAVGS PRKIQKETRK 540
SGNKDTDSEY LPSDTSDDDD DPYYYYYKSR RNRSKLRKKL VPSTKKGKSQ PFINPDSQGH 600
CPATSDSGIT DVAMSKSTCI SEFNQEHETE DCAESLNHAD SDVPPSNTMS PFNTSDYRFE 660
CICGELDQID RKPRVQCLKC HLWQHAKCVN YDEKNLKIKP FYCPHCLVAM EPVSTRATLI 720
ISPSSICHQW VDEINRHVRS SSLRVLVYQG VKKDGFLQPH FLAEQDIVII TYDVLRSELN 780
YVDIPHSNSE DGRRLRNQKR YMAIPSPLVA VEWWRICLDE AQMVECPTVK AAEMAQRLSG 840
INRWCISGTP VQRGLEDLFG LVVFLGIEPY CVKHWWVRLL YRPYCKKNPQ HLYSFIAKIL 900
WRSAKKDVID QIQIPPQTEE IHWLHFSPVE RHFYHRQHEV CCQDVVVKLR KISDWALKLS 960
SLDRRTVTSI LYPLLRLRQA CCHPQAVRGE FLPLQKSFEQ STFSFSTMTM EELLTSLQKK 1020
CGTECEEAHR QLVCALNGLA GIHIIKGEYA LAAELYREVL RSSEEHKGKL KTDSLQRLHA 1080
THNLMELLIA RHPGIPPTLR DGRLEEEAKQ LREHYMSKCN TEVAEAQQAL YPVQQTIHEL 1140
QRKIHSNSPW WLNVIHRAIE FTIDEELVQR VRNEITSNYK QQTGKLSMSE KGLQFLLTTQ 1200
MEELNKCQKL VREAVKNLEG PPSRNVIESA TVCHLRPARL PLNCCVFCKA DELFTEYESK 1260
LFSNTVKGQT AIFEEMIEDE EGLVDDRAPT TTRGLWAISE TERSMKAILS FAKSHRFDVE 1320
FVDEGSTSMD LFEAWKKEYK LLHEYWMALR NRVSAVDELA MATERLRVRD PREPKPNPPV 1380
LHIIEPHEVE QNRIKLLNDK AVATSQLQKK LGQLLYLTNL EKSQDKTSGG VNPEPCPICA 1440
RQLGKQWAVL TCGHCFCNEC ISIIIEQYSV GSHRSSIKCA ICRQTTSHKE ISYVFTSEKA 1500
NQEEDIPVKG SHSTKVEAVV RTLMKIQLRD PGAKALVFST WQDVLDIISK ALTDNNMEFA 1560
QISRVKTFQE NLSAFKRDPQ INILLLPLHT GSNGLTIIEA THVLLVEPIL NPAHELQAIG 1620
RVHRIGQTKP TIVHRFLIKA TIEERMQAML KTAERSHTNS SAKHSEASVL TVADLADLFT 1680
KETEELE 1687 
Gene Ontology
 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 
Interpro
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR005818; Histone_H1/H5.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N.
 IPR011991; WHTH_DNA-bd_dom.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00271; Helicase_C
 PF00538; Linker_histone
 PF00176; SNF2_N
 PF13639; zf-RING_2 
SMART
 SM00487; DEXDc
 SM00526; H15
 SM00490; HELICc
 SM00249; PHD
 SM00184; RING 
PROSITE
 PS51504; H15
 PS51194; HELICASE_CTER
 PS01359; ZF_PHD_1
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS