CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038906
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Map2k4 
Protein Synonyms/Alias
  
Gene Name
 Map2k4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
93SGQIMAVKRIRSTVDacetylation[1]
182VKALNHLKENLKIIHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 361 AA 
Protein Sequence
GKRKALKLNF ANPPVKSTAR FTLNPNTTGV QNPHIERLRT HSIESSGKLK ISPEQHWDFT 60
AEDLKDLGEI GRGAYGSVNK MVHKPSGQIM AVKRIRSTVD EKEQKQLLMD LDVVMRSSDC 120
PYIVQFYGAL FREGDCWICM ELMSTSFDKF YKYVYSVLDD VIPEEILGKI TLATVKALNH 180
LKENLKIIHR DIKPSNILLD RSGNIKLCDF GISGQLVDSI AKTRDAGCRP YMAPERIDPS 240
ASRQGYDVRS DVWSLGITLY ELATGRFPYP KWNSVFDQLT QVVKGDPPQL SNSEEREFSP 300
SFINFVNLCL TKDESKRPKY KELLKHPFIL MYEERTVEVA CYVCKILDQM PATPSSPMYV 360
D 361 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0032839; C:dendrite cytoplasm; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0043204; C:perikaryon; IDA:RGD.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0008545; F:JUN kinase kinase activity; IDA:RGD.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0045740; P:positive regulation of DNA replication; IMP:RGD.
 GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS