CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006704
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-dependent RNA helicase HrpB 
Protein Synonyms/Alias
  
Gene Name
 hrpB 
Gene Synonyms/Alias
 yadO; b0148; JW0144 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
75LAELLNEKPGDTVGYacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
  
Sequence Annotation
 DOMAIN 14 177 Helicase ATP-binding.
 DOMAIN 195 368 Helicase C-terminal.
 NP_BIND 27 34 ATP (By similarity).
 MOTIF 123 126 DEFH box.  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 809 AA 
Protein Sequence
MSSLPVAAVL PELLTALDCA PQVLLSAPTG AGKSTWLPLQ LLAHPGINGK IILLEPRRLA 60
ARNVAQRLAE LLNEKPGDTV GYRMRAQNCV GPNTRLEVVT EGVLTRMIQR DPELSGVGLV 120
ILDEFHERSL QADLALALLL DVQQGLRDDL KLLIMSATLD NDRLQQMLPE APVVISEGRS 180
FPVERRYLPL PAHQRFDDAV AVATAEMLRQ ESGSLLLFLP GVGEIQRVQE QLASRIGSDV 240
LLCPLYGALS LNDQRKAILP APQGMRKVVL ATNIAETSLT IEGIRLVVDC AQERVARFDP 300
RTGLTRLITQ RVSQASMTQR AGRAGRLEPG ISLHLIAKEQ AERAAAQSEP EILQSDLSGL 360
LMELLQWGCS DPAQMSWLDQ PPVVNLLAAK RLLQMLGALE GERLSAQGQK MAALGNDPRL 420
AAMLVSAKND DEAATAAKIA AILEEPPRMG NSDLGVAFSR NQPAWQQRSQ QLLKRLNVRG 480
GEADSSLIAP LLAGAFADRI ARRRGQDGRY QLANGMGAML DANDALSRHE WLIAPLLLQG 540
SASPDARILL ALLVDIDELV QRCPQLVQQS DTVEWDDAQG TLKAWRRLQI GQLTVKVQPL 600
AKPSEDELHQ AMLNGIRDKG LSVLNWTAEA EQLRLRLLCA AKWLPEYDWP AVDDESLLAA 660
LETWLLPHMT GVHSLRGLKS LDIYQALRGL LDWGMQQRLD SELPAHYTVP TGSRIAIRYH 720
EDNPPALAVR MQEMFGEATN PTIAQGRVPL VLELLSPAQR PLQITRDLSD FWKGAYREVQ 780
KEMKGRYPKH VWPDDPANTA PTRRTKKYS 809 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR007502; Helicase-assoc_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR010225; RNA_helicase_ATP-dep_DEAH_HrpB.
 IPR013689; RNA_helicase_ATP-dep_HrpB_C. 
Pfam
 PF00270; DEAD
 PF04408; HA2
 PF00271; Helicase_C
 PF08482; HrpB_C 
SMART
 SM00487; DEXDc
 SM00847; HA2
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS