CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018394
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA-dihydrouridine synthase A 
Protein Synonyms/Alias
  
Gene Name
 dusA 
Gene Synonyms/Alias
 STM4243 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
313YLSENAHKAGADVAVacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Reference proteome; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 332 AA 
Protein Sequence
MQPETQSSAL PAYRFSIAPM LDWTDRHCRY FLRLLSRQTQ LYTEMVTTGA IIHGKGDYLA 60
YSEEEHPVAL QLGGSDPAQL AHCAKLAEAR GYDEINLNVG CPSDRVQNGM FGACLMGNAQ 120
LVADCVKAMR DVVSIPVTVK TRIGIDDQDS YAFLCDFIDT VSGQGECEMF IIHARKAWLS 180
GLSPKENREI PPLDYPRVYQ LKRDFPHLTM SINGGIKSLE EAKEHLRHMD GVMVGREAYQ 240
NPGILAAVDR EIFGADTTDA DPVAVVRAMY PYIERELSQG AYLGHITRHM LGLFQGIPGA 300
RQWRRYLSEN AHKAGADVAV LEQALKLVAD KR 332 
Gene Ontology
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0017150; F:tRNA dihydrouridine synthase activity; IEA:InterPro.
 GO:0002943; P:tRNA dihydrouridine synthesis; IEA:GOC. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR004653; tRNA_dU_YjbN.
 IPR001269; tRNA_hU_synthase.
 IPR018517; tRNA_hU_synthase_CS. 
Pfam
 PF01207; Dus 
SMART
  
PROSITE
 PS01136; UPF0034 
PRINTS