CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016592
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Periodic tryptophan protein 2 homolog 
Protein Synonyms/Alias
  
Gene Name
 Pwp2 
Gene Synonyms/Alias
 Pwp2h 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
55NTLPLATKYNIKCVGacetylation[1, 2]
233LKAPRGWKADILQREubiquitination[3]
260RETTIRGKTTPAEQEacetylation[2]
700DMSSRHFKPEIRVTSacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 REPEAT 12 50 WD 1.
 REPEAT 53 93 WD 2.
 REPEAT 94 132 WD 3.
 REPEAT 142 181 WD 4.
 REPEAT 186 225 WD 5.
 REPEAT 286 325 WD 6.
 REPEAT 328 368 WD 7.
 REPEAT 371 410 WD 8.
 REPEAT 413 452 WD 9.
 REPEAT 456 498 WD 10.
 REPEAT 499 538 WD 11.
 REPEAT 541 580 WD 12.
 REPEAT 603 642 WD 13.
 REPEAT 700 740 WD 14.
 MOD_RES 700 700 N6-acetyllysine (By similarity).
 MOD_RES 746 746 Phosphothreonine (By similarity).
 MOD_RES 895 895 Phosphoserine.
 MOD_RES 898 898 Phosphoserine.
 MOD_RES 902 902 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 919 AA 
Protein Sequence
MKFAYRFSNL LGTVYRCGNL NFTHDGNSVI SPVGNRVTVF DLKNNRSNTL PLATKYNIKC 60
VGLSPDGRLA IIVDEGGAAL LVSLVCRSVL HHFHFKGSVH SVSFSPDGRK FVVTKGNIAQ 120
MYHAPGKKRE FNAFVLDKTY FGPYDETTCI DWTDDSKCFV VGSKDMSTWV FGAERWDNLI 180
YYALSGHKDA IVACFFESNS LDLYSLSQDG ALCVWQCDTP PEGLRLKAPR GWKADILQRE 240
KEEEEEDEEE GDRETTIRGK TTPAEQERVG KVKYSRLAKY FLNKEGDFNN LTSAAYHKKT 300
HLLVTGFASG IFHLHELPEF NLIHSLSISD QRVASVAINS SGDWIAFGCS GMGQLLVWEW 360
QSESYVLKQQ GHFNSMVALA YSPDGQYIVT GGDDGKVKVW NTLSGFCFVT LTEHSSGVTG 420
VTFTTTGHVI VTSSLDGTVR AFDLHRYRNF RTFTSPRPTQ FSCVAVDSSG EIVSAGAQDS 480
FEIFVWSMQT GRLLDVLSGH EGPVSGLCFN PMKSILASAS WDKTVRLWDM FDSWRTKETL 540
TLTSDALAVT FRPDGAELAV ATLNSQITFW DPENAVQVGS IEGRHDLKTG RKELDKITAK 600
HSAKGKAFTT LCYSADGQSI LAGGMSKFVC LYHVREQILV KRFELSCNLS LDAMEEFLNR 660
RKMTEFGNLA LIDQDAGEEN GVAVPLPGVR KGDMSSRHFK PEIRVTSLRF SPTGRCWAAT 720
STEGLLIFSL DAQMLFDPFE LDTSVTPGRI REALRQREFT RAILMAFRLN EKKLAQEALE 780
AVPQNEIEVV STSLPELYVV KVLEFLAASF EESRHLEFYL IWTQKLLMSH GQRLKSRAGQ 840
LLPVVQFLQK GLQRHLDDVS KLCDWNRFNI QYVLAVSKQR GMKRTLEPVD TEEDSDASDE 900
DSLHLLRAAG EEEEEEMLI 919 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR027145; PWP2.
 IPR011047; Quinonprotein_ADH-like_supfam.
 IPR007148; SSU_processome_Utp12.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF04003; Utp12
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.