CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023110
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein Helios 
Protein Synonyms/Alias
 Ikaros family zinc finger protein 2 
Gene Name
 IKZF2 
Gene Synonyms/Alias
 HELIOS; ZNFN1A2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
166IKLHSGEKPFKCPFCubiquitination[1]
283RKSSTPQKFVGEKLMubiquitination[1]
288PQKFVGEKLMRFSYPacetylation[2]
288PQKFVGEKLMRFSYPubiquitination[1]
438KQSPAYMKEDVKALDubiquitination[1]
442AYMKEDVKALDTTKAubiquitination[1]
448VKALDTTKAPKGSLKubiquitination[1]
455KAPKGSLKDIYKVFNubiquitination[1]
459GSLKDIYKVFNGEGEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Associates with Ikaros at centromeric heterochromatin. 
Sequence Annotation
 ZN_FING 112 134 C2H2-type 1.
 ZN_FING 140 162 C2H2-type 2.
 ZN_FING 168 190 C2H2-type 3.
 ZN_FING 196 219 C2H2-type 4.
 ZN_FING 471 493 C2H2-type 5.
 ZN_FING 499 523 C2H2-type 6.
 MOD_RES 56 56 Phosphoserine.
 MOD_RES 78 78 Phosphoserine.
 MOD_RES 79 79 Phosphoserine.
 MOD_RES 288 288 N6-acetyllysine.  
Keyword
 Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
METEAIDGYI TCDNELSPER EHSNMAIDLT SSTPNGQHAS PSHMTSTNSV KLEMQSDEEC 60
DRKPLSREDE IRGHDEGSSL EEPLIESSEV ADNRKVQELQ GEGGIRLPNG KLKCDVCGMV 120
CIGPNVLMVH KRSHTGERPF HCNQCGASFT QKGNLLRHIK LHSGEKPFKC PFCSYACRRR 180
DALTGHLRTH SVGKPHKCNY CGRSYKQRSS LEEHKERCHN YLQNVSMEAA GQVMSHHVPP 240
MEDCKEQEPI MDNNISLVPF ERPAVIEKLT GNMGKRKSST PQKFVGEKLM RFSYPDIHFD 300
MNLTYEKEAE LMQSHMMDQA INNAITYLGA EALHPLMQHP PSTIAEVAPV ISSAYSQVYH 360
PNRIERPISR ETADSHENNM DGPISLIRPK SRPQEREASP SNSCLDSTDS ESSHDDHQSY 420
QGHPALNPKR KQSPAYMKED VKALDTTKAP KGSLKDIYKV FNGEGEQIRA FKCEHCRVLF 480
LDHVMYTIHM GCHGYRDPLE CNICGYRSQD RYEFSSHIVR GEHTFH 526 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS