CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008192
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 YLP motif-containing protein 1 
Protein Synonyms/Alias
 Nuclear protein ZAP3; ZAP113 
Gene Name
 YLPM1 
Gene Synonyms/Alias
 C14orf170; ZAP3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
272LESGAKNKSTEQQQAubiquitination[1]
490KTWQGHMKATQSYLQubiquitination[2, 3]
1857VAKLIRDKEVEFGGPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation (By similarity). 
Sequence Annotation
 REGION 1901 1908 Involved in interaction with PPP1CA (By  
Keyword
 Alternative splicing; Complete proteome; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1951 AA 
Protein Sequence
MYPNWGRYGG SSHYPPPPVP PPPPVALPEA SPGPGYSSST TPAAPSSSGF MSFREQHLAQ 60
LQQLQQMHQK QMQCVLQPHH LPPPPLPPPP VMPGGGYGDW QPPPPPMPPP PGPALSYQKQ 120
QQYKHQMLHH QRDGPPGLVP MELESPPESP PVPPGSYMPP SQSYMPPPQP PPSYYPPTSS 180
QPYLPPAQPS PSQSPPSQSY LAPTPSYSSS SSSSQSYLSH SQSYLPSSQA SPSRPSQGHS 240
KSQLLAPPPP SAPPGNKTTV QQEPLESGAK NKSTEQQQAA PEPDPSTMTP QEQQQYWYRQ 300
HLLSLQQRTK VHLPGHKKGP VVAKDTPEPV KEEVTVPATS QVPESPSSEE PPLPPPNEEV 360
PPPLPPEEPQ SEDPEEDARL KQLQAAAAHW QQHQQHRVGF QYQGIMQKHT QLQQILQQYQ 420
QIIQPPPHIQ TMSVDMQLRH YEMQQQQFQH LYQEWEREFQ LWEEQLHSYP HKDQLQEYEK 480
QWKTWQGHMK ATQSYLQEKV NSFQNMKNQY MGNMSMPPPF VPYSQMPPPL PTMPPPVLPP 540
SLPPPVMPPA LPATVPPPGM PPPVMPPSLP TSVPPPGMPP SLSSAGPPPV LPPPSLSSAG 600
PPPVLPPPSL SSTAPPPVMP LPPLSSATPP PGIPPPGVPQ GIPPQLTAAP VPPASSSQSS 660
QVPEKPRPAL LPTPVSFGSA PPTTYHPPLQ SAGPSEQVNS KAPLSKSALP YSSFSSDQGL 720
GESSAAPSQP ITAVKDMPVR SGGLLPDPPR SSYLESPRGP RFDGPRRFED LGSRCEGPRP 780
KGPRFEGNRP DGPRPRYEGH PAEGTKSKWG MIPRGPASQF YITPSTSLSP RQSGPQWKGP 840
KPAFGQQHQQ QPKSQAEPLS GNKEPLADTS SNQQKNFKMQ SAAFSIAADV KDVKAAQSNE 900
NLSDSQQEPP KSEVSEGPVE PSNWDQNVQS METQIDKAQA VTQPVPLANK PVPAQSTFPS 960
KTGGMEGGTA VATSSLTADN DFKPVGIGLP HSENNQDKGL PRPDNRDNRL EGNRGNSSSY 1020
RGPGQSRMED TRDKGLVNRG RGQAISRGPG LVKQEDFRDK MMGRREDSRE KMNRGEGSRD 1080
RGLVRPGSSR EKVPGGLQGS QDRGAAGSRE RGPPRRAGSQ ERGPLRRAGS RERIPPRRAG 1140
SRERGPPRGP GSRERGLGRS DFGRDRGPFR PEPGDGGEKM YPYHRDEPPR APWNHGEERG 1200
HEEFPLDGRN APMERERLDD WDRERYWREC ERDYQDDTLE LYNREDRFSA PPSRSHDGDR 1260
RGPWWDDWER DQDMDEDYNR EMERDMDRDV DRISRPMDMY DRSLDNEWDR DYGRPLDEQE 1320
SQFRERDIPS LPPLPPLPPL PPLDRYRDDR WREERNREHG YDRDFRDRGE LRIREYPERG 1380
DTWREKRDYV PDRMDWERER LSDRWYPSDV DRHSPMAEHM PSSHHSSEMM GSDASLDSDQ 1440
GLGGVMVLSQ RQHEIILKAA QELKMLREQK EQLQKMKDFG SEPQMADHLP PQESRLQNTS 1500
SRPGMYPPPG SYRPPPPMGK PPGSIVRPSA PPARSSVPVT RPPVPIPPPP PPPPLPPPPP 1560
VIKPQTSAVE QERWDEDSFY GLWDTNDEQG LNSEFKSETA AIPSAPVLPP PPVHSSIPPP 1620
GPVPMGMPPM SKPPPVQQTV DYGHGRDIST NKVEQIPYGE RITLRPDPLP ERSTFETEHA 1680
GQRDRYDRER DREPYFDRQS NVIADHRDFK RDRETHRDRD RDRGVIDYDR DRFDRERRPR 1740
DDRAQSYRDK KDHSSSRRGG FDRPSYDRKS DRPVYEGPSM FGGERRTYPE ERMPLPAPSL 1800
SHQPPPAPRV EKKPESKNVD DILKPPGRES RPERIVVIMR GLPGSGKTHV AKLIRDKEVE 1860
FGGPAPRVLS LDDYFITEVE KEEKDPDSGK KVKKKVMEYE YEAEMEETYR TSMFKTFKKT 1920
LDDGFFPFII LDAINDRVRH FDQFWSAAKT KGFEVYLAEM SADNQTCGKR NIHGRKLKEI 1980
NKMADHWETA PRHMMRLDIR SLLQDAAIEE VEMEDFDANI EEQKEEKKDA EEEESELGYI 2040
PKSKWEMDTS EAKLDKLDGL RTGTKRKRDW EAIASRMEDY LQLPDDYDTR ASEPGKKRVR 2100
WADLEEKKDA DRKRAIGFVV GQTDWEKITD ESGHLAEKAL NRTKYI 2146 
Gene Ontology
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IEA:Compara.
 GO:0032204; P:regulation of telomere maintenance; IEA:Compara. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR026314; YLP_motif_con_p1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS