UniProt Accession

 A9C4B9_HUMAN; A9C4B9 

Genbank Protein ID

 AC012314 

Genbank Nucleotide ID

  

Protein Name

 tRNA-splicing endonuclease subunit Sen34 

Protein Synonyms/Alias

  

Gene Name

 TSEN34 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
90	SLALTSFKRQQEESF	ubiquitination	[1, 2, 3]
118	RRQELLEKITEGQAA	ubiquitination	[1, 2, 3]
126	ITEGQAAKKQKLEQA	ubiquitination	[1]
129	GQAAKKQKLEQASGA	ubiquitination	[1]
210	LDWRVQSKDWPHAGR	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 251 AA 

Protein Sequence

Gene Ontology

 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0000213; F:tRNA-intron endonuclease activity; IEA:InterPro.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:InterPro. 

Interpro

 IPR011856; tRNA_endonuc-like_dom.
 IPR006677; tRNA_intron_Endonuc_cat-like. 

Pfam

 PF01974; tRNA_int_endo 

SMART

  

PROSITE

  

PRINTS