UniProt Accession

 APH1A_HUMAN; Q96BI3; B4DQK0; Q5TB22; Q5TB23; Q969R6; Q9BVG0; Q9Y386 

Genbank Protein ID

 AF508787; AY113698; AY113699; AF151835; AY358951; AK027879; AK075295; AK298832; AL138795; AL138795; CH471121; CH471121; CH471121; BC001230; BC008732; BC009501; BC015568; BC017699; BC020590 

Genbank Nucleotide ID

 AAN63816.1; AAM61955.1; AAM61956.1; AAD34072.1; AAQ89310.1; BAG51389.1; BAC11529.1; BAG60962.1; CAI22811.1; CAI22812.1; EAW53565.1; EAW53566.1; EAW53567.1; AAH01230.1; AAH08732.1; AAH09501.1; AAH15568.1; AAH17699.1; AAH20590.1 

Protein Name

 Gamma-secretase subunit APH-1A 

Protein Synonyms/Alias

 APH-1a; Aph-1alpha; Presenilin-stabilization factor 

Gene Name

 APH1A 

Gene Synonyms/Alias

 PSF; CGI-78; UNQ579/PRO1141 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
92	VFRFAYYKLLKKADE	ubiquitination	[1]
95	FAYYKLLKKADEGLA	ubiquitination	[1]
96	AYYKLLKKADEGLAS	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Membrane; Notch signaling pathway; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 265 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HGNC.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IDA:HGNC.
 GO:0004175; F:endopeptidase activity; IEA:Compara.
 GO:0042987; P:amyloid precursor protein catabolic process; IMP:UniProtKB.
 GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
 GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
 GO:0031293; P:membrane protein intracellular domain proteolysis; IMP:UniProtKB.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0007220; P:Notch receptor processing; IMP:UniProtKB.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
 GO:0016485; P:protein processing; IDA:HGNC. 

Interpro

 IPR009294; Aph-1. 

Pfam

 PF06105; Aph-1 

SMART

  

PROSITE

  

PRINTS