CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014282
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear receptor corepressor 1 
Protein Synonyms/Alias
 N-CoR; N-CoR1; Retinoid X receptor-interacting protein 13; RIP13 
Gene Name
 Ncor1 
Gene Synonyms/Alias
 Rxrip13 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
152KDPAFGVKHEAPSSPsumoylation[1]
260IFEGLGPKVELPLYNsumoylation[1]
1117AAPLTYIKQEEFSPRsumoylation[1]
1330LKYPKQIKRESPPIRsumoylation[1]
Reference
 [1] SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.
 Tiefenbach J, Novac N, Ducasse M, Eck M, Melchior F, Heinzel T.
 Mol Biol Cell. 2006 Apr;17(4):1643-51. [PMID: 16421255] 
Functional Description
 Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. 
Sequence Annotation
 DOMAIN 435 486 SANT 1.
 DOMAIN 622 673 SANT 2.
 REGION 1 373 Interaction with ZBTB33 and HEXIM1 (By
 REGION 254 312 Interaction with SIN3A/B.
 REGION 1510 2453 Interaction with C1D.
 REGION 2050 2129 ID1.
 REGION 2065 2068 Required for interaction with RARA in the
 REGION 2226 2287 ID2.
 MOTIF 1949 1953 CORNR box 1.
 MOTIF 2073 2077 CORNR box 2.
 MOTIF 2277 2281 CORNR box 3.
 MOD_RES 224 224 Phosphoserine.
 MOD_RES 1011 1011 Phosphoserine.
 MOD_RES 1122 1122 Phosphoserine (By similarity).
 MOD_RES 1206 1206 Phosphoserine (By similarity).
 MOD_RES 1423 1423 N6-acetyllysine (By similarity).
 MOD_RES 1481 1481 Phosphoserine.
 MOD_RES 1993 1993 Phosphoserine (By similarity).
 MOD_RES 1997 1997 Phosphoserine (By similarity).
 MOD_RES 2116 2116 Phosphoserine.
 MOD_RES 2165 2165 Phosphoserine.
 MOD_RES 2198 2198 Phosphoserine.
 MOD_RES 2412 2412 Phosphothreonine (By similarity).
 MOD_RES 2449 2449 Phosphoserine.
 MOD_RES 2451 2451 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2453 AA 
Protein Sequence
MSSSGYPPNQ GAFSTEQSRY PSHSVQYTFP SARHQQEFAV PDYRSSHLEV SQASQLLQQQ 60
QQQQLRRRPS LLSEFHPGSD RPQERRSGYE QFHPGPSPVD HDSLESKRPR LEQVSDSHFQ 120
RISAAVLPLV HTLPEGLRSS ANAKKDPAFG VKHEAPSSPL SGQPCGDDQN ASPSKLSKEE 180
LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY 240
DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR 300
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR KQREQQERFQ 360
RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMFDA EQRRVKFINM 420
NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD KFIQHPKNFG LIASYLERKS VPDCVLYYYL 480
TKKNENYKAL VRRNYGKRRG RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDDEEKDD 540
KEDSKETTKE KDRTEATAEE PEEREQVTPR GRKTANSQGR GKGRVTRSMT SEAAAANAAA 600
AATEEPPPPL PPPPEPISTE PVETSRWTEE EMEVAKKGLV EHGRNWAAIA KMVGTKSEAQ 660
CKNFYFNYKR RHNLDNLLQQ HKQKASRKPR EERDVSQCES VASTVSAQED EDIEASNEEE 720
NPEDSEGAEN SSDTESAPSP SPVEAAKSSE DSSENAASRG NTEPVAELEA TTDPAPCASP 780
SSAVPTTKPA ERESVEAQVT DSASAETAEP MDVDHEECGA EGSSVLDPPA PTKADSVDPE 840
MQVPENTASK GEGDAKERDL ESTSEKTEAR DEDVVVAEQI ERPEPQSDDD SSATCSADEG 900
VDGEPERQRV FPMDAKPSLL TPPGSILISS PIKPNLLDLP QLQHRAAVIP PMVSCTPCNI 960
PIGTPVSGYA LYQRHIKAMH ESALLEEQRQ RQEQVDLECR SSTSPCSTSK SPNREWEVLQ 1020
PAPHQVITNL PEGVRLPTTR PTRPPPPLIP SSKTTVASEK PSFIMGGSIS QGTPGTYLSS 1080
HNQAYPQEAP KPSVGSISLG LPRQQESTKA APLTYIKQEE FSPRSQNSQP EGLLVRAQHE 1140
GVVRGTAGAV QEGSITRGTP ASKISVETIS SLRGSITQGT PALPQAGIPT EALVKGPVSR 1200
MPIEESSPEK VREEAASKGH VIYEGKSGHI LSYDNIKNAR EGTRSPRTAH EMSLKRSYEA 1260
VEGSIKQGMS MRESPVSAPL EGLICRALPR GSPHSDLKER TVLSGSIMQG TPRATAESFE 1320
DGLKYPKQIK RESPPIRAFE GAITKGKPYD GITTIKEMGR SIHEIPRQDI LTQESRKTPE 1380
VVQSTRPIIE GSISQGTPIK FDNNSGQSAI KHNVKSLITG PSKLPRGMLE IVPENIKVVE 1440
RGKYEDVKAG EPVRARHTSV VSSGPSVLRS TLHEAPKAQL SPGLYDDSSA RRTPVSYQNT 1500
ISRGSPMMNR TSDVSSSKSA SHERKSTLTP TQRESIPAKS PVPGVDPIVS HSPFDPHHRS 1560
SAAGEVYRSH LPTHLDPAMP FHRALDPAAA YLLQRQLSPT PGYPSQYQLY AMENTRQTIL 1620
NDYITSQQMQ VNLRPDVTRG LSPREQPLGL PYPATRGIID LTNMPPTILV PHAGGTSTPP 1680
MDRITYIPGT QVTFPPRPYN AASLSPGHPT HLAAAASAER EREREREKER ERERERERER 1740
ERERIAAAPA DLYLRPGSEQ PGRPGSHGYV RSPSPSVRTQ ETILQQRPSV FQGTNGTSVI 1800
TPLDPTAQLR IMPLPSGGPS ISQGLPASRY NTAADALAAL VDAAASAPQM DVSKTKESKH 1860
EAARLEENLR SRSAAVSEQQ QLEQKNLEVE KRSVQCVCTS SALPSGKAQP HASVVYSEAG 1920
KDKGPPPKSR YEEELRTRGK TTITAANFID VIITRQIASD KDARERGSQS SDSSSSLSSH 1980
RYETASDAIE VISPASSPAP PQEKPQAYQP DMVKANQAEN ESTRQYEGPL HHYRSQQESP 2040
SPQQQPPLPP SSQSEGMGQV PRTHRLITLA DHICQIITQD FARNQVPSQA STSTFQTSPS 2100
ALSSTPVRTK TSSRYSPESQ SQTVLHPRPG PRVSPENLVD KSRGSRPGKS PERSHIPSEP 2160
YEPISPPQGP AVHEKQDSML LLSQRGVDPA EQRSDSRSPG SISYLPSFFT KLESTSPMVK 2220
SKKQEIFRKL NSSGGGDSDM AAAQPGTEIF NLPAVTTSGA VSSRSHSFAD PASNLGLEDI 2280
IRKALMGSFD DKVEDHGVVM SHPVGIMPGS ASTSVVTSSE ARRDEGEPSP HAGVCKPKLI 2340
NKSNSRKSKS PIPGQSYLGT ERPSSVSSVH SEGDYHRQTP GWAWEDRPSS TGSTQFPYNP 2400
LTIRMLSSTP PTQIACAPSA ITQAAPHQQN RIWEREPAPL LSAQYETLSD SDD 2453 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005667; C:transcription factor complex; IPI:MGI.
 GO:0017053; C:transcriptional repressor complex; IPI:MGI.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0035033; F:histone deacetylase regulator activity; IDA:MGI.
 GO:0046965; F:retinoid X receptor binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0046966; F:thyroid hormone receptor binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IGI:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0002361; P:CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IMP:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0032922; P:circadian regulation of gene expression; IGI:MGI.
 GO:0060318; P:definitive erythrocyte differentiation; IMP:MGI.
 GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase cascade; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0031065; P:positive regulation of histone deacetylation; IDA:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IGI:MGI.
 GO:0021794; P:thalamus development; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom. 
Pfam
 PF00249; Myb_DNA-binding 
SMART
 SM00717; SANT 
PROSITE
 PS51293; SANT 
PRINTS