| Tag | Content |
|---|
| CPLM ID | CPLM-023557 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Guanylate cyclase soluble subunit alpha-2 |
Protein Synonyms/Alias | GCS-alpha-2 |
Gene Name | Gucy1a2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 665 | PTTYQLLKREDSFTF | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Has guanylyl cyclase on binding to the beta-1 subunit. |
Sequence Annotation | DOMAIN 519 646 Guanylate cyclase. |
Keyword | cGMP biosynthesis; Complete proteome; Cytoplasm; GTP-binding; Lyase; Nucleotide-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 730 AA |
Protein Sequence | MSRRKISSES FSSLGSDYLE TSPEEEGECP LSKLCWNGSR SPPGPPGSRA AAMAATPVPA 60
ASVAAAAAAV AAGSKRAQRR RRVNLDSLGE SISLLTAPSP QTIHMTLKRT LQYYEHQVIG 120
YRDAEKNFHN ISNRCSSADH SNKEEIEDVS GILRCTANVL GLKFQEIQER FGEEFFKICF 180
DENERVLRAV GSTLQDFFNG FDALLEHIRT SFGKQATLES PSFLCKELPE GTLKLHYFHP 240
HHTVGFAMLG MIKAAGKRIY HLNVEVEQIE NEKFCSDGST PSNYSCLTFL IKECETTQIT 300
KNIPQGTSQI PTDLRISINT FCRTFPFHLM FDPNMVVLQL GEGLRKQLRC DNHKVLKFED 360
CFEIVSPKVN ATFDRVLLRL STPFVIRTKP EASGTDNEDK VMEIKGQMIH VPESNAILFL 420
GSPCVDKLDE LIGRGLHLSD IPIHDATRDV ILVGEQAKAQ DGLKKRMDKL KATLEKTHQA 480
LEEEKKKTVD LLYSIFPGDV AQQLWQRQQV QARKFDDVTM LFSDIVGFTA ICAQCTPMQV 540
ISMLNELYTR FDHQCGFLDI YKVETIGDAY CVASGLHRKS LCHAKPIALM ALKMMELSEE 600
VLTPDGRPIQ MRIGIHSGSV LAGVVGVRMP RYCLFGNNVT LASKFESGSH PRRINISPTT 660
YQLLKREDSF TFIPRSREEL PDNFPKEIPG VCYFLELRTG PKPPKPSLSS SRIKKVSYNI 720
GTMFLRETSL 730 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0004383; F:guanylate cyclase activity; IDA:RGD. GO:0020037; F:heme binding; IEA:InterPro. GO:0046982; F:protein heterodimerization activity; NAS:RGD. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0030828; P:positive regulation of cGMP biosynthetic process; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |