UniProt Accession

 RHOU_MOUSE; Q9EQT3 

Genbank Protein ID

 AF378088; AB051827 

Genbank Nucleotide ID

 AAK83341.1; BAB18639.1 

Protein Name

 Rho-related GTP-binding protein RhoU 

Protein Synonyms/Alias

 Rho GTPase-like protein ARHU; Wnt-1 responsive Cdc42 homolog 1; WRCH-1 

Gene Name

 Rhou 

Gene Synonyms/Alias

 Arhu; G28k; Wrch1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
180	KVLIELDKCKEKPVP	ubiquitination	[1]
251	DKVRDLSKSWWRKYC	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). 

Sequence Annotation

 NP_BIND 59 66 GTP (By similarity).
 NP_BIND 106 110 GTP (By similarity).
 NP_BIND 164 167 GTP (By similarity).
 LIPID 259 259 S-palmitoyl cysteine (By similarity).  

Keyword

 Cell junction; Cell membrane; Cell projection; Complete proteome; Golgi apparatus; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IMP:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0030036; P:actin cytoskeleton organization; IDA:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IDA:MGI.
 GO:0016601; P:Rac protein signal transduction; IDA:MGI.
 GO:0008360; P:regulation of cell shape; IDA:MGI. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.