CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011953
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Forkhead box protein F1 
Protein Synonyms/Alias
 Forkhead-related activator 1; FREAC-1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1 
Gene Name
 FOXF1 
Gene Synonyms/Alias
 FKHL5; FREAC1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MSSAPEKQQPPHGGacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
 Probable transcription activator for a number of lung- specific genes. 
Sequence Annotation
 DNA_BIND 47 138 Fork-head.  
Keyword
 Activator; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 379 AA 
Protein Sequence
MSSAPEKQQP PHGGGGGGGG GGGAAMDPAS SGPSKAKKTN AGIRRPEKPP YSYIALIVMA 60
IQSSPTKRLT LSEIYQFLQS RFPFFRGSYQ GWKNSVRHNL SLNECFIKLP KGLGRPGKGH 120
YWTIDPASEF MFEEGSFRRR PRGFRRKCQA LKPMYSMMNG LGFNHLPDTY GFQGSAGGLS 180
CPPNSLALEG GLGMMNGHLP GNVDGMALPS HSVPHLPSNG GHSYMGGCGG AAAGEYPHHD 240
SSVPASPLLP TGAGGVMEPH AVYSGSAAAW PPSASAALNS GASYIKQQPL SPCNPAANPL 300
SGSLSTHSLE QPYLHQNSHN APAELQGIPR YHSQSPSMCD RKEFVFSFNA MASSSMHSAG 360
GGSYYHQQVT YQDIKPCVM 379 
Gene Ontology
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0008301; F:DNA binding, bending; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; IBA:RefGenome.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0060446; P:branching involved in open tracheal system development; IMP:DFLAT.
 GO:0003214; P:cardiac left ventricle morphogenesis; IMP:DFLAT.
 GO:0016337; P:cell-cell adhesion; IEA:Compara.
 GO:0071345; P:cellular response to cytokine stimulus; IEA:Compara.
 GO:0071407; P:cellular response to organic cyclic compound; IEA:Compara.
 GO:0014822; P:detection of wounding; IEA:Compara.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0097070; P:ductus arteriosus closure; IMP:DFLAT.
 GO:0048613; P:embryonic ectodermal digestive tract morphogenesis; IMP:DFLAT.
 GO:0048617; P:embryonic foregut morphogenesis; IEA:Compara.
 GO:0003197; P:endocardial cushion development; IMP:DFLAT.
 GO:0061030; P:epithelial cell differentiation involved in mammary gland alveolus development; IEA:Compara.
 GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Compara.
 GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Compara.
 GO:0030198; P:extracellular matrix organization; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IMP:DFLAT.
 GO:0048371; P:lateral mesodermal cell differentiation; IEA:Compara.
 GO:0048286; P:lung alveolus development; IEA:Compara.
 GO:0060463; P:lung lobe morphogenesis; IEA:Compara.
 GO:0060426; P:lung vasculature development; IMP:DFLAT.
 GO:0090131; P:mesenchyme migration; IEA:Compara.
 GO:0007494; P:midgut development; IMP:DFLAT.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0043305; P:negative regulation of mast cell degranulation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0031016; P:pancreas development; IMP:DFLAT.
 GO:0007389; P:pattern specification process; IBA:RefGenome.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Compara.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0051150; P:regulation of smooth muscle cell differentiation; IEA:Compara.
 GO:0060461; P:right lung morphogenesis; IEA:Compara.
 GO:0051145; P:smooth muscle cell differentiation; IEA:Compara.
 GO:0007224; P:smoothened signaling pathway; IEA:Compara.
 GO:0001756; P:somitogenesis; IEA:Compara.
 GO:0060438; P:trachea development; IEA:Compara.
 GO:0072189; P:ureter development; IMP:DFLAT.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0060841; P:venous blood vessel development; IMP:DFLAT. 
Interpro
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00250; Fork_head 
SMART
 SM00339; FH 
PROSITE
 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 
PRINTS
 PR00053; FORKHEAD.