UniProt Accession

 PVR_HUMAN; P15151; B4DTS9; P15152; Q15267; Q15268; Q96BJ1 

Genbank Protein ID

 M24407; M24406; X64116; X64117; X64118; X64119; X64120; X64121; X64122; X64123; X64116; X64117; X64118; X64119; X64120; X64121; X64122; X64123; X64116; X64117; X64118; X64119; X64120; X64122; X64123; AK300349; AC068948; BC015542 

Genbank Nucleotide ID

 AAA36461.1; AAA36462.1; CAA45478.1; CAA45478.1; CAA45478.1; CAA45478.1; CAA45478.1; CAA45478.1; CAA45478.1; CAA45478.1; CAA45479.1; CAA45479.1; CAA45479.1; CAA45479.1; CAA45479.1; CAA45479.1; CAA45479.1; CAA45479.1; CAA45480.1; CAA45480.1; CAA45480.1; CAA45480.1; CAA45480.1; CAA45480.1; CAA45480.1; BAG62091.1; AAF69803.1; AAH15542.1 

Protein Name

 Poliovirus receptor 

Protein Synonyms/Alias

 Nectin-like protein 5; NECL-5; CD155 

Gene Name

 PVR 

Gene Synonyms/Alias

 PVS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
90	GPSYSESKRLEFVAA	ubiquitination	[1, 2]
153	QNTAEVQKVQLTGEP	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. 

Sequence Annotation

 DOMAIN 24 139 Ig-like V-type.
 DOMAIN 145 237 Ig-like C2-type 1.
 DOMAIN 244 328 Ig-like C2-type 2.
 REGION 368 372 DYNLT1 binding.
 MOTIF 396 401 ITIM motif.
 MOD_RES 398 398 Phosphotyrosine.
 CARBOHYD 105 105 N-linked (GlcNAc...).
 CARBOHYD 120 120 N-linked (GlcNAc...) (complex).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
 CARBOHYD 218 218 N-linked (GlcNAc...) (Potential).
 CARBOHYD 237 237 N-linked (GlcNAc...) (Potential).
 CARBOHYD 278 278 N-linked (GlcNAc...).
 CARBOHYD 307 307 N-linked (GlcNAc...).
 CARBOHYD 313 313 N-linked (GlcNAc...) (Potential).
 DISULFID 49 123
 DISULFID 166 221 By similarity.
 DISULFID 266 312 By similarity.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 417 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IDA:HPA.
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005615; C:extracellular space; TAS:ProtInc.
 GO:0016021; C:integral to membrane; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; IMP:BHF-UCL.
 GO:0042271; P:susceptibility to natural killer cell mediated cytotoxicity; IMP:BHF-UCL.
 GO:0060370; P:susceptibility to T cell mediated cytotoxicity; IDA:BHF-UCL.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013106; Ig_V-set.
 IPR003596; Ig_V-set_subgr.
 IPR013151; Immunoglobulin. 

Pfam

 PF08205; C2-set_2
 PF00047; ig
 PF07686; V-set 

SMART

 SM00406; IGv 

PROSITE

 PS50835; IG_LIKE 

PRINTS