CPLM-020908

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-020908

UniProt Accession

CNPY3_MOUSE; Q9DAU1; Q571I0; Q8BUS5; Q8BUV5; Q8C0C5

Genbank Protein ID

AF361644; AK005532; AK031742; AK049358; AK082340; AK082749; AK085617; AK086940; AK143428; BC013549; AK220209

Genbank Nucleotide ID

AAK52494.1; BAB24103.1; BAC27534.1; BAC33707.1; BAC38471.1; BAC38599.1; BAC39489.1; BAC39769.1; BAE25373.1; AAH13549.1; BAD90134.1

Protein Name

Protein canopy homolog 3

Protein Synonyms/Alias

Protein associated with Tlr4; Trinucleotide repeat-containing gene 5 protein

Gene Name

Cnpy3

Gene Synonyms/Alias

Prat4a; Tnrc5

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
202	ANHVLKGKDTSCLAE	acetylation	[1]

Reference

[1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]

Functional Description

Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses.

Sequence Annotation

DOMAIN 47 269 Saposin B-type.
CARBOHYD 153 153 N-linked (GlcNAc...) (Potential).
DISULFID 49 206 By similarity.
DISULFID 52 194 By similarity.
DISULFID 104 166 By similarity.

Keyword

Alternative splicing; Chaperone; Coiled coil; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunity; Innate immunity; Reference proteome; Signal.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

276 AA

Protein Sequence

MESMSELAPR CLLFPLLLLL PLLLLPAPKL GPSPAGAEET DWVRLPSKCE VCKYVAVELK 60
SAFEETGKTK EVIDTGYGIL DGKGSGVKYT KSDLRLIEVT ETICKRLLDY SLHKERTGSN 120
RFAKGMSETF ETLHNLVHKG VKVVMDIPYE LWNETSAEVA DLKKQCDVLV EEFEEVIEDW 180
YRNHQEEDLT EFLCANHVLK GKDTSCLAER WSGKKGDIAS LGGKKSKKKR SGVKGSSSGS 240
SKQRKELGGL GEDANAEEEE GVQKASPLPH SPPDEL 276

Gene Ontology

GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.

Interpro

IPR021852; DUF3456.

Pfam

PF11938; DUF3456

SMART

PROSITE

PS50015; SAP_B

PRINTS