UniProt Accession

 2ABD_HUMAN; Q66LE6; A8KAK0; Q5SQJ2; Q9P1Y7 

Genbank Protein ID

 AK293065; AL732395; BC047379; AB040974 

Genbank Nucleotide ID

 BAF85754.1; CAI16703.1; AAH47379.1; BAA96065.1 

Protein Name

 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform 

Protein Synonyms/Alias

 PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform delta 

Gene Name

 PPP2R2D 

Gene Synonyms/Alias

 KIAA1541 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	KSLEIEEKINKIRWL	ubiquitination	[1]
104	EIEEKINKIRWLPQQ	ubiquitination	[1]
126	STNDKTIKLWKISER	ubiquitination	[1]
129	DKTIKLWKISERDKR	ubiquitination	[1]
143	RAEGYNLKDEDGRLR	ubiquitination	[1, 2]
273	ALCDRHSKFFEEPED	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). 

Sequence Annotation

 REPEAT 32 71 WD 1.
 REPEAT 97 138 WD 2.
 REPEAT 181 219 WD 3.
 REPEAT 230 270 WD 4.
 REPEAT 289 327 WD 5.
 REPEAT 344 385 WD 6.
 REPEAT 420 452 WD 7.  

Keyword

 Cell cycle; Cell division; Complete proteome; Cytoplasm; Mitosis; Polymorphism; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 453 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000159; C:protein phosphatase type 2A complex; ISS:UniProtKB.
 GO:0008601; F:protein phosphatase type 2A regulator activity; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0010458; P:exit from mitosis; ISS:UniProtKB.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR000009; PP2A_PR55.
 IPR018067; PP2A_PR55_CS.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

  

SMART

 SM00320; WD40 

PROSITE

 PS01024; PR55_1
 PS01025; PR55_2
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00600; PP2APR55.