CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045294
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transcription elongation factor SPT5 
Protein Synonyms/Alias
  
Gene Name
 SUPT5H 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54ELGEYYMKKYAKSSVubiquitination[1]
55LGEYYMKKYAKSSVGubiquitination[2]
86QQLLPGVKDPNLWTVacetylation[3]
150IKARMSLKDWFAKRKubiquitination[2, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 164 AA 
Protein Sequence
DQWEDGAEDI LEKEEIEASN IDNVVLDEDR SGARRLQNLW RDQREEELGE YYMKKYAKSS 60
VGETVYGGSD ELSDDITQQQ LLPGVKDPNL WTVKCKIGEE RATAISLMRK FIAYQFTDTV 120
DYVEPSQNTI SLKMIPRIDY DRIKARMSLK DWFAKRKKFK RPPQ 164 
Gene Ontology
 GO:0032784; P:regulation of DNA-dependent transcription, elongation; IEA:InterPro.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:InterPro. 
Interpro
 IPR022581; Spt5_N.
 IPR017071; TF_Spt5.
 IPR005100; TF_Spt5_NGN-domain. 
Pfam
 PF03439; Spt5-NGN
 PF11942; Spt5_N 
SMART
  
PROSITE
  
PRINTS