CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041937
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysosomal trafficking regulator, isoform CRA_a 
Protein Synonyms/Alias
 Lysosomal-trafficking regulator 
Gene Name
 Lyst 
Gene Synonyms/Alias
 mCG_18823 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1707DYSKYINKDILRCDEubiquitination[1]
2135IADANPEKQNLLGRPubiquitination[1]
2849VSKGSWQKTVNNNQQubiquitination[1]
2958CYLTIPNKYLLRDRQubiquitination[1]
3177SIYRNLSKPIAVQYKubiquitination[1]
3391RALETMIKTYGQTPRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3787 AA 
Protein Sequence
MSTDSNSLAR EFLIDVNQLC NAVVQRAEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS 60
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE QQATDFNLPL SSDIILTKEK NSSLQKSTQG 120
KLYLEGSAPS GQVSAKVNLF RKIRRQRKST HRYSVRDARK TQLSTSDSEG NSDEKSTVVS 180
KHRRLHALPR FLTQSPKEGH LVAKPDPSAT KEQVLSDTMS VENSREVILR QDSNGDILSE 240
PAALSILSNM NNSPFDLCHV LLSLLEKVCK FDIALNHNSS LALSVVPTLT EFLAGFGDCC 300
NQSDTLEGQL VSAGWTEEPV ALVQRMLFRT VLHLMSVDVS TAEAMPESLR KNLTELLRAA 360
LKIRACLEKQ PEPFSPRQKK TLQEVQEGFV FSKYRHRALL LPELLEGVLQ LLISCLQSAA 420
SNPFYFSQAM DLVQEFIQHQ GFNLFETAVL QMEWLLSRDG VPSEAAEHLK ALINSVIKIM 480
STVKKVKSEQ LHHSMCTRKR HRRCEYSHFM QHHRDLSGLL VSAFKNQLSK SPFEETAEGD 540
VQYPERCCCI AVCAHQCLRL LQQVSLSTTC VQILSGVHSV GICCCMDPKS VIVPLLHAFK 600
LPALKAFQQH ILNVLSKLLL DQLGGAELSP RIKKAACNIC TVDSDQLAKL GETLQGTLCG 660
AGPTSGLPSP SYRFQGILPS SGSEDLLWKW DALEAYQSFV FQEDRLHNIQ IANHICNLIQ 720
KGNVVVQWKL YNYIFNPVLQ RGVELVHHCQ QLSIPSAQTH MCSQLKQYLP QEVLQIYLKT 780
LPVLLKSRVI RDLFLSCNGV NQIIELNYLD GIRSHSLKAF ETLIVSLGEQ QKDAAVLDVD 840
GLDIQQELPS LSVGPSLHKQ QASSDSPCSL RKFYASLREP DPKKRKTIHQ DVHINTINLF 900
LCVAFLCVSK EADSDRESAN ESEDTSGYDS TASEPLSHML PCLSLENVVL PSPECLHHAA 960
DIWSMCRWIY MLNSVFQKQF HRLGGFQVCH ELIFMIIQKL FRSHTEDQGR RQGEMSRNEN 1020
QELIRISYPE LTLKGDVSSA TAPDLGFLRK SADSVRGFQS QPVLPTSAEQ IVATESVPGE 1080
RKAFMSQQSE TSLQSIRLLE SLLAICLHSA RACQQKMELE LPSQGLSVEN ILCELREHLS 1140
QSKVAETELA KPLFDALLRV ALGNHSADLG PGDAVTEKSH PSEEELLSQP GDFSEEAEDS 1200
QCCSLKLLGE EEGYEADSES NPEDVDTQDD GVELNPEAEG FSGSIVSNNL LENLTHGEII 1260
YPEICMLGLN LLSASKAKLD VLAHVFESFL KIVRQKEKNI SLLIQQGTVK ILLGGFLNIL 1320
TQTNSDFQAC QRVLVDLLVS LMSSRTCSED LTLLLRIFLE KSPCTEILLL GIHKIVESDF 1380
TMSPSQCLTF PFLHTPSLSN GVLSQKPPGI LNSKALGLLR RARISRGKKE ADRESFPYRL 1440
LSSWHIAPIH LPLLGQNCWP HLSEGFSVSL WFNVEYIHES ESAAERGKRV KKRNKPSVLE 1500
DSSFEGAEGD RPEVTESINP GDRLIEDGCI HLISLGSKAL MIQVWADPHS GTFIFRVCMD 1560
SNDDTKAVSL AQVESQENIF FPSKWQHLVL TYIQHPQGKK NVHGEISIWV SGQRKTDVIL 1620
DFVLPRKTSL SSDSNKTFCM IGHCLTSQEE SLQLAGKWDL GNLLLFNGAK IGSQEAFFLY 1680
ACGPNYTSIM PCKYGQPVID YSKYINKDIL RCDEIRDLFM TKKEVDVGLL IESLSVVYTT 1740
CCPAQYTIYE PVIRLKGQVK TQPSQRPFSS KEAQSILLEP SQLKGLQPTE CKAIQGILHE 1800
IGGAGTFVFL FARVVELSSC EETQALALRV ILSLIKYSQQ RTQELENCNG LSMIHQVLVK 1860
QKCIVGFHIL KTLLEGCCGE EVIHVSEHGE FKLDVESHAI IQDVKLLQEL LLDWKIWNKA 1920
EQGVWETLLA ALEVLIRVEH HQQQFNIKQL LNAHVVHHFL LTCQVLQEHR EGQLTSMPRE 1980
VCRSFVKIIA EVLGSPPDLE LLTVIFNFLL AVHPPTNTYV CHNPTNFYFS LHIDGKIFQE 2040
KVQSLAYLRH SSSGGQAFPS PGFLVISPSA FTAAPPEGTS SSNIVPQRMA AQMVRSRSLP 2100
AFPTYLPLIR AQKLAASLGF SVDKLQNIAD ANPEKQNLLG RPYALKTSKE EAFISSCESA 2160
KTVCEMEALL GAHASANGVS RGSPRFPRAR VDHKDVGTEP RSDDDSPGDE SYPRRPDNLK 2220
GLASFQRSQS TVASLGLAFP SQNGSAVASR WPSLVDRNAD DWENFTFSPA YEASYNRATS 2280
THSVIEDCLI PICCGLYELL SGVLLVLPDA MLEDVMDRII QADILLVLVN HPSPAIQQGV 2340
IKLLHAYINR ASKEQKDKFL KNRGFSLLAN QLYLHRGTQE LLECFVEMFF GRPIGLDEEF 2400
DLEEVKHMEL FQKWSVIPVL GLIETSLYDN VLLHNALLLL LQVLNSCSKV ADMLLDNGLL 2460
YVLCNTVAAL NGLEKNIPVN EYKLLACDIQ QLFIAVTIHA CSSSGTQYFR VIEDLIVLLG 2520
YLHNSKNKRT QNMALALQLR VLQAALEFIR STANHDSESP VHSPSAHRHS VPPKRRSIAG 2580
SRKFPLAQTE SLLMKMRSVA SDELHSMMQR RMSQEHPSQA SEAELAQRLQ RLTILAVNRI 2640
IYQELNSDII DILRTPENTS QSKTSVSQTE ISEEDMHHEQ PSVYNPFQKE MLTYLLDGFK 2700
VCIGSSKTSV SKQQWTKILG SCKETLRDQL GRLLAHILSP THTVQERKQI LEIVHEPAHQ 2760
DILRDCLSPS PQHGAKLVLY LSELIHNHQD ELSEEEMDTA ELLMNALKLC GHKCIPPSAP 2820
SKPELIKIIR EEQKKYESEE SVSKGSWQKT VNNNQQSLFQ RLDFKSKDIS KIAADITQAV 2880
SLSQGIERKK VIQHIRGMYK VDLSASRHWQ ECIQQLTHDR AVWYDPIYYP TSWQLDPTEG 2940
PNRERRRLQR CYLTIPNKYL LRDRQKSEGV LRPPLSYLFE DKTHSSFSST VKDKAASESI 3000
RVNRRCISVA PSRETAGELL LGKCGMYFVE DNASDAVESS SLQGELEPAS FSWTYEEIKE 3060
VHRRWWQLRD NAVEIFLTNG RTLLLAFDNN KVRDDVYQSI LTNNLPNLLE YGNITALTNL 3120
WYSGQITNFE YLTHLNKHAG RSFNDLMQYP VFPFILSDYV SETLDLNDPS IYRNLSKPIA 3180
VQYKEKEDRY VDTYKYLEEE YRKGAREDDP MPPVQPYHYG SHYSNSGTVL HFLVRMPPFT 3240
KMFLAYQDQS FDIPDRTFHS TNTTWRLSSF ESMTDVKELI PEFFYLPEFL VNREGFDFGV 3300
RQNGERVNHV NLPPWARNDP RLFILIHRQA LESDHVSQNI CHWIDLVFGY KQKGKASVQA 3360
INVFHPATYF GMDVSAVEDP VQRRALETMI KTYGQTPRQL FHTAHASRPG AKLNIEGELP 3420
AAVGLLVQFA FRETREPVKE VTHPSPLSWI KGLKWGEYVG SPSAPVPVVC FSQPHGERFG 3480
SLQALPTRAI CGLSRNFCLL MTYNKEQGVR SMNNTNIQWS AILSWGYADN ILRLKSKQSE 3540
PPINFIQSSQ QHQVTSCAWV PDSCQLFTGS KCGVITAYTN RLTSSTPSEI EMESQMHLYG 3600
HTEEITGLCV CKPYSVMISV SRDGTCIVWD LNRLCYVQSL AGHKSPVTAV SASETSGDIA 3660
TVCDSAGGGS DLRLWTVNGD LVGHVHCREI ICSVAFSNQP EGVSINVIAG GLENGIVRLW 3720
STWDLKPVRE ITFPKSNKPI ISLTFSCDGH HLYTANSEGT VIAWCRKDQQ RVKLPMFYSF 3780
LSSYAAG 3787 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0007596; P:blood coagulation; IMP:MGI.
 GO:0042742; P:defense response to bacterium; IMP:MGI.
 GO:0042832; P:defense response to protozoan; IMP:MGI.
 GO:0051607; P:defense response to virus; IMP:MGI.
 GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; IEA:Compara.
 GO:0030595; P:leukocyte chemotaxis; IMP:MGI.
 GO:0007040; P:lysosome organization; IMP:MGI.
 GO:0033364; P:mast cell secretory granule organization; IMP:MGI.
 GO:0032438; P:melanosome organization; IMP:MGI.
 GO:0007017; P:microtubule-based process; IMP:MGI.
 GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Compara.
 GO:0002446; P:neutrophil mediated immunity; IMP:MGI.
 GO:0055091; P:phospholipid homeostasis; IMP:MGI.
 GO:0006644; P:phospholipid metabolic process; IMP:MGI.
 GO:0032816; P:positive regulation of natural killer cell activation; IMP:MGI.
 GO:0042493; P:response to drug; IMP:MGI.
 GO:0033299; P:secretion of lysosomal enzymes; IMP:MGI.
 GO:0002456; P:T cell mediated immunity; IMP:MGI. 
Interpro
 IPR000409; BEACH_dom.
 IPR023362; PH-BEACH_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF02138; Beach
 PF00400; WD40 
SMART
 SM01026; Beach
 SM00320; WD40 
PROSITE
 PS50197; BEACH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS