CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024768
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Desmoplakin 
Protein Synonyms/Alias
 DP 
Gene Name
 Dsp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
152QPCDAYQKRLLQLQEubiquitination[1]
166EQMRALYKAISVPRVubiquitination[1]
197SGWDEFTKRLTGECLubiquitination[1]
453QVQNLVNKSKKIVQLubiquitination[1]
482LRALCDYKQDQKIVHubiquitination[1]
841KSLLATMKTELQKAQubiquitination[1]
1045DLKLKNTKIEVLEEEubiquitination[1]
1085QAECSQFKAKLVSLEubiquitination[1]
1156NDYDQLQKARQCEKEubiquitination[1]
1528RVQYDLQKANNSATEubiquitination[1]
2714FIGFEGVKGKKKMSAubiquitination[1]
2726MSAAEAVKEKWLPYEubiquitination[1]
2728AAEAVKEKWLPYEAGubiquitination[1]
2784QDISSYAKILTCPKTubiquitination[1]
2823EAASVSSKGLPSPYNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. 
Sequence Annotation
 REPEAT 190 283 Spectrin 1.
 REPEAT 284 387 Spectrin 2.
 REPEAT 388 458 Spectrin 3a.
 DOMAIN 459 527 SH3.
 REPEAT 528 557 Spectrin 3b.
 REPEAT 558 639 Spectrin 4.
 REPEAT 666 781 Spectrin 5.
 REPEAT 782 895 Spectrin 6.
 REPEAT 2021 2057 Plectin 1.
 REPEAT 2058 2095 Plectin 2.
 REPEAT 2096 2133 Plectin 3.
 REPEAT 2134 2171 Plectin 4.
 REPEAT 2175 2209 Plectin 5.
 REPEAT 2210 2245 Plectin 6.
 REPEAT 2263 2300 Plectin 7.
 REPEAT 2301 2338 Plectin 8.
 REPEAT 2339 2376 Plectin 9.
 REPEAT 2377 2414 Plectin 10.
 REPEAT 2418 2452 Plectin 11.
 REPEAT 2468 2505 Plectin 12.
 REPEAT 2519 2556 Plectin 13.
 REPEAT 2622 2659 Plectin 14.
 REPEAT 2660 2697 Plectin 15.
 REPEAT 2736 2773 Plectin 16.
 REPEAT 2774 2811 Plectin 17.
 REGION 1 1068 Globular 1.
 REGION 1 596 Interacts with plakophilin 1 and junction
 REGION 1069 1957 Central fibrous rod domain.
 REGION 1958 2882 Globular 2.
 REGION 1972 2220 4.5 X 38 AA tandem repeats (Domain A).
 REGION 2256 2458 4.5 X 38 AA tandem repeats (Domain B).
 REGION 2621 2833 4.5 X 38 AA tandem repeats (Domain C).
 REGION 2835 2858 6 X 4 AA tandem repeats of G-S-R-[SR].
 MOD_RES 22 22 Phosphoserine (By similarity).
 MOD_RES 177 177 Phosphoserine (By similarity).
 MOD_RES 178 178 Phosphoserine (By similarity).
 MOD_RES 188 188 Phosphoserine (By similarity).
 MOD_RES 2036 2036 Phosphoserine (By similarity).
 MOD_RES 2219 2219 Phosphoserine (By similarity).
 MOD_RES 2221 2221 Phosphoserine (By similarity).
 MOD_RES 2827 2827 Phosphoserine (By similarity).
 MOD_RES 2832 2832 Phosphoserine (By similarity).
 MOD_RES 2836 2836 Phosphoserine (By similarity).
 MOD_RES 2860 2860 Phosphoserine (By similarity).
 MOD_RES 2864 2864 Phosphothreonine (By similarity).
 MOD_RES 2879 2879 Phosphoserine (By similarity).
 LIPID 2492 2492 Omega-hydroxyceramide glutamate ester (By  
Keyword
 Cardiomyopathy; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Lipoprotein; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2883 AA 
Protein Sequence
MSCNGGSHPR INTLGRMTRA ESGPDLRYEM TYSGGGGGGG GGGGGGTSRT FYSHSRRCTV 60
NDQNSDGYCQ TGTMSRHQNQ NTIQEMLQNC SDCLMRAELI AQPELKFGEG MQLAWNRELD 120
EYFTQANDQM EIIDGLIREM RQMGQPCDAY QKRLLQLQEQ MRALYKAISV PRVRRASSKG 180
AGGYTCQSGS GWDEFTKRLT GECLGWMRQQ REEMDLMAWG VDAGSVEQHI NSHRSIHNTI 240
GDYRWQLDKI KADLREKSAI YQLEEEYENL LKASFERMDH LRQLQNIIQA TSREIMWIND 300
CEEEELLYDW SDKNTNIAQK QEAFSIRMSQ LEVKEKELNK LKQESDQLVL NQHPASDKIE 360
AYMDTLQTQW SWILQITKCI DVHLKENAAY FQFFEEAQST EAYLKGLQDS IRKKYPCDKN 420
MPLQHLLEQI KELEKEREKI IEYKRQVQNL VNKSKKIVQL KPRNPDYRSN KPIILRALCD 480
YKQDQKIVHK GDECILKDNN ERSKWYVTGP GGVDMLVPSV GLIIPPPNPL AVDLSCKIEQ 540
YYEAILALWN QLYINMKSLV SWHYCMIDIE KIRAMTIAKL KTMRQEDYMK TIEDLELHYQ 600
DFIKNSQGSE MFGDDDKRRM QSQFTDAQKH YQTLVIQLPG HPQHQTVTKT EITHLGTCQD 660
VNHNKVIETN RENDKQETWL LMELQKIRRQ MEHCEARMTL KNLLLAEQGS THHITVKINE 720
LKSVQNDSQA LAEVLNQLKD MLANFRGSEK YCYLQNEIFG LFQKLENING VSDGYLNSLC 780
SVRALLQAIL QTEDMLKVYE ARLTEEETVC LDLDKVEAYR CGLKKIKNDL NLKKSLLATM 840
KTELQKAQQI HSQSSQQYPL YDLDLGKFTE KVTQLTDRWQ KIDKQIDFRL WDLEKQIKQL 900
RNYRDNYQSF CKWLYDAKRR QDSLESMKFG DSNTVMRFLN EQKNLHSEIS GKRDKSEEVH 960
KIAELCANSI KDYELQLASY TSGLETLLNI PIKRTMVQSP SGVILQEAAD IHARYIELLT 1020
RSGDYYRFLS EMLKSLEDLK LKNTKIEVLE EELRLARDAN SENCNKNKFL DQNLQKYQAE 1080
CSQFKAKLVS LEELKRQAEL DGKSAKQNLD KCYGQIKELN EKITRLTYEI EDEKRRRKTV 1140
EDRFDQQKND YDQLQKARQC EKENLSWQKL ESEKAIKEKE YEIERLRVLL QEEGARKREY 1200
ENELAKVRNH YNEEMSNLRN KYETEINITK TTIKEISMQK EDDSKNLRNQ MDRLSRENRD 1260
LKDEIVRLND SILQATEQRR RAEENALQQK ACGSETMQKK QRLEIELKQV IQQRSEDNAR 1320
HKQSLEEAAK TIQDKNKEIE RLKAEYQEEA KRRWEYENEL SKVRNSYDEE IISLKNQFET 1380
EINITKTTIH QLTMQKEEDT SGYRAQIDNL TRENRSLCEE VKRLKNTLAQ TTENLRRVEE 1440
NAQQQKATGS EMSQRKQQLE IELRQVTQMR TEESMRYKQS LDDAAKTIQD KNKEIERLKQ 1500
LVDKETNERK CLEDENSKLQ RVQYDLQKAN NSATEAMSKL KVQEQELTRL RIDYERVSQE 1560
RTVKDQDITR IQSSLKDLQL QKQKAEEELS RLKRTASDES SKRKMLEEEL EAMRRSLKEQ 1620
AVKITNLTQQ LEQASIVKKR SEDDLRQQRD VLDGHVREKQ RTQEELRRLS LDVEALRRQL 1680
VQEQENVKQA HLRNEHFQKA IEDKSRSLNE SKIEIERLQS LTENLTKEHL MLEEELRNLR 1740
LEYDDLRRGR SEADSDKNST ISELRSQLQI SNNRTLELQG LINDLQRERE NLRQEIEKFQ 1800
KQALEASNRI QESKSQCTQV VQERESLLVK IKVLEQDKAR LQRLEDELNR AKATLEAESR 1860
VKQRLECEKQ QIQNDLNQWK TQYSRKEETI RKIESEREKS EREKNSLRSE IERLQAEIKR 1920
IEERCRRKLE DSSRETQSQL ESERCRLQKE IEKLRQRPYG SHRETQTEYE WTVDSSKLVF 1980
DGLRKKVTAM QLYECQLIDK TTLDKLLKGK KSVEEVASEI QPFLRGAGAI AGASASPKEK 2040
YSLVEAKRKK FITPESTVML LEAQAATGGI IDPHRNEKLT VDNAVARDLI DFDDRQQIYT 2100
AEKAITGFDD PFSGKTVSVS EAIKKNLIDR ETGMRLLEAQ LASGGVVDPV NSVFLPKDVA 2160
LARGLIDRDL YRSLNDPRDS QKNFVDPITK KKVSYMQLRE RCRIEPHTGL LLLSVQKRSM 2220
SFQGIRQPVT VTELVDSGIL RPSTVNELES GQISYDEVGE RIKDFLQGSS CIAGIYNETT 2280
KQKLGIYEAM KIGLVRPGTA LELLEAQAAT GFIVDPVSNL RLPVEEAYKR GLVGIEFKEK 2340
LLSAERAVTG YNDPETGNII SLFQAMNKEL IEKGHGIRLL EAQIATGGII DPKESHRLPV 2400
DMAYKRGYFN EELSEILSDP SDDTKGFFDP NTEENLTYLQ LKERCIKDEE TGLCLLPLKE 2460
KKKQVQTSQK NTLRKRRVVI VDPETNKEMS VQEAYKKGLI DYDTFKELCE QECEWEEITI 2520
TGSDGSTRVV LVDRKTGSQY DIQDAIDKGL VDRKFFDQYR SGSLSLTQFA DMISLKNGVG 2580
NSSGLGGSVN DDVFSSSRHD SVSKISTISS VRNLTIRSSS LSDPLEESSP IAAIFDTENL 2640
EKISIAEGIE RGIVDSITGQ RLLEAQACTG GIIHPTTGQK LSLQDAVNQG LIDQDMATRL 2700
KPAQKAFIGF EGVKGKKKMS AAEAVKEKWL PYEAGQRFLE FQFLTGGLVD PEVHGRISTE 2760
EAIRKGFIDG RAAQRLQDIS SYAKILTCPK TKLKISYKDA MNRSMVEDIT GLRLLEAASV 2820
SSKGLPSPYN MSAPGSRSGS RSGSRSGSRS GSRSGSRRGS FDATGNSSYS YSYSFSSSSI 2880
GGY 2883 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0001533; C:cornified envelope; IEA:Compara.
 GO:0030057; C:desmosome; IDA:MGI.
 GO:0014704; C:intercalated disc; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005198; F:structural molecule activity; IEA:Compara.
 GO:0034332; P:adherens junction organization; IMP:MGI.
 GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IEA:Compara.
 GO:0016337; P:cell-cell adhesion; IMP:MGI.
 GO:0002934; P:desmosome organization; IMP:BHF-UCL.
 GO:0045109; P:intermediate filament organization; IMP:BHF-UCL.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0018149; P:peptide cross-linking; IEA:Compara.
 GO:0071896; P:protein localization to adherens junction; IMP:BHF-UCL.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Compara.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IEA:Compara.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0003223; P:ventricular compact myocardium morphogenesis; IMP:BHF-UCL. 
Interpro
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin. 
Pfam
 PF00681; Plectin 
SMART
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
 PS50002; SH3 
PRINTS