Tag | Content |
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CPLM ID | CPLM-005579 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3 beta-hydroxysteroid dehydrogenase type 5 |
Protein Synonyms/Alias | 3 beta-hydroxysteroid dehydrogenase type V; 3-beta-HSD V; 3-beta-hydroxy-5-ene steroid dehydrogenase; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; Progesterone reductase |
Gene Name | Hsd3b5 |
Gene Synonyms/Alias | Hsd3b |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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27 | VQMLVQEKELQEVRV | acetylation | [1] | 44 | RTFSPKHKEELSKLQ | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Exhibits only 3-ketosteroid reductase activity in the presence of NADPH and does not function as an isomerase. |
Sequence Annotation | ACT_SITE 155 155 Proton acceptor (By similarity). BINDING 159 159 NAD (By similarity). MOD_RES 42 42 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Endoplasmic reticulum; Membrane; Mitochondrion; NADP; Oxidoreductase; Reference proteome; Steroidogenesis; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 373 AA |
Protein Sequence | MPGWSCLVTG AGGFLGQRIV QMLVQEKELQ EVRVLYRTFS PKHKEELSKL QTKAKVTVLR 60 GDIVDAQFLR RACQGMSVII HTAAALDIAG FLPRQTILDV NVKGTQLLLD ACVEASVPAF 120 IYSSSTGVAG PNSYKETILN DREEEHREST WSNPYPYSKR MAEKAVLAAN GSILKNGGTF 180 HTCALRLPFI YGEESQIIST MVNRALKNNS IIKRHATFSI ANPVYVGNAA WAHILAARGL 240 RDPEKSQSIQ GQFYYISDDT PHQSYDDLNY TLSKEWGFCL DSSWSLPLPL LYWLAFLLET 300 VSFLLRPFYN YRPPFNRFMV TILNSVFTIS YKKAQRDLGY EPLVSWEEAK QKTSEWIGTL 360 VEQHRETLDT KSQ 373 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD. GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IDA:RGD. GO:0051287; F:NAD binding; IDA:RGD. GO:0005496; F:steroid binding; IDA:RGD. GO:0042448; P:progesterone metabolic process; IDA:RGD. GO:0050810; P:regulation of steroid biosynthetic process; IDA:RGD. GO:0006694; P:steroid biosynthetic process; IDA:RGD. |
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