| Tag | Content |
|---|
| CPLM ID | CPLM-023318 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SH2B adapter protein 3 |
Protein Synonyms/Alias | Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk |
Gene Name | SH2B3 |
Gene Synonyms/Alias | LNK |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 373 | HGPISRVKAAQLVQL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase (By similarity). |
Sequence Annotation | DOMAIN 194 307 PH.
DOMAIN 364 462 SH2.
MOD_RES 150 150 Phosphoserine. |
Keyword | Complete proteome; Diabetes mellitus; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 575 AA |
Protein Sequence | MNGPALQPSS PSSAPSASPA AAPRGWSEFC ELHAVAAARE LARQYWLFAR EHPQHAPLRA 60
ELVSLQFTDL FQRYFCREVR DGRAPGRDYR DTGRGPPAKA EASPEPGPGP AAPGLPKARS 120
SEELAPPRPP GPCSFQHFRR SLRHIFRRRS AGELPAAHTA AAPGTPGEAA ETPARPGLAK 180
KFLPWSLARE PPPEALKEAV LRYSLADEAS MDSGARWQRG RLALRRAPGP DGPDRVLELF 240
DPPKSSRPKL QAACSSIQEV RWCTRLEMPD NLYTFVLKVK DRTDIIFEVG DEQQLNSWMA 300
ELSECTGRGL ESTEAEMHIP SALEPSTSSS PRGSTDSLNQ GASPGGLLDP ACQKTDHFLS 360
CYPWFHGPIS RVKAAQLVQL QGPDAHGVFL VRQSETRRGE YVLTFNFQGI AKHLRLSLTE 420
RGQCRVQHLH FPSVVDMLHH FQRSPIPLEC GAACDVRLSS YVVVVSQPPG SCNTVLFPFS 480
LPHWDSESLP HWGSELGLPH LSSSGCPRGL SPEGLPGRSS PPEQIFHLVP SPEELANSLQ 540
HLEHEPVNRA RDSDYEMDSS SRSHLRAIDN QYTPL 575 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0042301; F:phosphate ion binding; IEA:Compara. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004871; F:signal transducer activity; IEA:InterPro. GO:0007596; P:blood coagulation; TAS:Reactome. GO:0030154; P:cell differentiation; IEA:Compara. GO:0035162; P:embryonic hemopoiesis; IEA:Compara. GO:0035556; P:intracellular signal transduction; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |