UniProt Accession

 AIP_MOUSE; O08915; Q3UJM2 

Genbank Protein ID

 U85489; AK146390; BC075614 

Genbank Nucleotide ID

 AAB59009.1; BAE27133.1; AAH75614.1 

Protein Name

 AH receptor-interacting protein 

Protein Synonyms/Alias

 AIP; Aryl-hydrocarbon receptor-interacting protein 

Gene Name

 Aip 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
266	NKYDDNVKAYFKRGK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. 

Sequence Annotation

 DOMAIN 31 121 PPIase FKBP-type.
 REPEAT 179 212 TPR 1.
 REPEAT 265 298 TPR 2.  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 330 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003712; F:transcription cofactor activity; IPI:MGI.
 GO:0051082; F:unfolded protein binding; ISS:HGNC.
 GO:0051344; P:negative regulation of cyclic-nucleotide phosphodiesterase activity; IEA:Compara.
 GO:0022417; P:protein maturation by protein folding; ISS:HGNC.
 GO:0006626; P:protein targeting to mitochondrion; ISS:HGNC.
 GO:0010738; P:regulation of protein kinase A signaling cascade; IEA:Compara.
 GO:0006805; P:xenobiotic metabolic process; IPI:MGI. 

Interpro

 IPR001179; PPIase_FKBP_dom.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00254; FKBP_C 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS