| Tag | Content |
|---|
| CPLM ID | CPLM-016023 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arginine-glutamic acid dipeptide repeats protein |
Protein Synonyms/Alias | Atrophin-2 |
Gene Name | Rere |
Gene Synonyms/Alias | Atr2; Kiaa0458 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 378 | ESSYDAGKALQRLVK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. |
Sequence Annotation | DOMAIN 103 283 BAH.
DOMAIN 284 387 ELM2.
DOMAIN 391 443 SANT.
ZN_FING 507 532 GATA-type.
MOD_RES 53 53 Phosphoserine (By similarity).
MOD_RES 56 56 Phosphoserine (By similarity).
MOD_RES 304 304 Phosphoserine (By similarity).
MOD_RES 600 600 Phosphoserine.
MOD_RES 642 642 Phosphoserine (By similarity).
MOD_RES 656 656 Phosphoserine.
MOD_RES 675 675 Phosphoserine.
MOD_RES 679 679 Phosphoserine.
MOD_RES 1098 1098 Phosphoserine (By similarity). |
Keyword | Coiled coil; Complete proteome; Developmental protein; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1558 AA |
Protein Sequence | MTADKDKDKD KEKDRDRDRD RERDKRDKAR ESENARPRRS CTLEGGAKNY AESDHSEDED 60
NDNNSATTEE SNKKSRKKPP KKKSRYERTD TGEITSYITE DDVVYRPGDC VYIESRRPNT 120
PYFICSIQDF KLVHSSQACC RSPAPAFCDP PACSLPVAPQ PPQHLSEAGR GPGGSKRDHL 180
LMNVKWYYRQ SEVPDSVYQH LVQDRHNEND SGRELVITDP VIKNRELFIS DYVDTYHAAA 240
LRGKCNISHF SDIFAAREFK ARVDSFFYIL GYNPETRRLN STQGEIRVGP SHQAKLPDLQ 300
PFPSPDGDTV TQHEELVWMP GVSDCDLLMY LRAARSMAAF AGMCDGGSTE DGCVAASRDD 360
TTLNALNTLH ESSYDAGKAL QRLVKKPVPK LIEKCWTEDE VKRFVKGLRQ YGKNFFRIRK 420
ELLPSKETGE LITFYYYWKK TPEAASSRAH RRHRRQAVFR RIKTRTASTP VNTPSRPPSS 480
EFLDLSSASE DDFDSEDSEQ ELKGYACRHC FTTTSKDWHH GGRENILLCT DCRIHFKKYG 540
ELPPIEKPVD PPPFMFKPVK EEDDGLSGKH SMRTRRSRGS MSTLRSGRKK QPTSPDGRAS 600
PINEDIRSSG RNSPSAASTS SNDSKAETVK KSAKKVKEEA ASPLKSTKRQ REKVASDTED 660
TDRITSKKTK TQEISRPNSP SEGEGESSDS RSVNDEGSSD PKDIDQDNRS TSPSIPSPQD 720
NESDSDSSAQ QQMLQAQPPA LQAPSGAASA PSTAPPGTPQ LPTQGPTPSA TAVPPQGSPA 780
TSQPPNQTQS TVAPAAHTHI QQAPTLHPPR LPSPHPPLQP MTAPPSQSSA QPHPQPSLHS 840
QGPPGPHSLQ TGPLLQHPGP PQPFGLPSQP SQGQGPLGPS PAAAHPHSTI QLPASQSALQ 900
PQQPPREQPL PPAPLAMPHI KPPPTTPIPQ LPAPQAHKHP PHLSGPSPFS LNANLPPPPA 960
LKPLSSLSTH HPPSAHPPPL QLMPQSQPLP SSPAQPPGLT QSQSLPPPAA SHPTTGLHQV 1020
PSQSPFPQHP FVPGGPPPIT PPSCPPTSTP PAGPSSSSQP PCSAAVSSGG SVPGAPSCPL 1080
PAVQIKEEAL DEAEEPESPP PPPRSPSPEP TVVDTPSHAS QSARFYKHLD RGYNSCARTD 1140
LYFMPLAGSK LAKKREEAIE KAKREAEQKA REEREREKEK EKERERERER EREAERAAKA 1200
SSSAHEGRLS DPQLSGPGHM RPSFEPPPTT IAAVPPYIGP DTPALRTLSE YARPHVMSPT 1260
NRNHPFYMPL NPTDPLLAYH MPGLYNVDPT IRERELRERE IREREIRERE LRERMKPGFE 1320
VKPPELDPLH PATNPMEHFA RHSALTIPPA AGPHPFASFH PGLNPLERER LALAGPQLRP 1380
EMSYPDRLAA ERIHAERMAS LTSDPLARLQ MFNVTPHHHQ HSHIHSHLHL HQQDPLHQGS 1440
AGPVHPLVDP LTAGPHLARF PYPPGTLPNP LLGQPPHEHE MLRHPVFGTP YPRDLPGAIP 1500
PPMSAAHQLQ AMHAQSAELQ RLAMEQQWLH GHPHMHGGHL PSQEDYYSRL KKEGDKQL 1558 |
Gene Ontology | GO:0000118; C:histone deacetylase complex; IPI:MGI. GO:0005739; C:mitochondrion; IEA:Compara. GO:0016605; C:PML body; IEA:UniProtKB-SubCell. GO:0003682; F:chromatin binding; IEA:InterPro. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006338; P:chromatin remodeling; IPI:MGI. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |