CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021782
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fatty acid desaturase 3 
Protein Synonyms/Alias
  
Gene Name
 Fads3 
Gene Synonyms/Alias
 MNCb-0629 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
409RRVAPLVKAFCAKHGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 DOMAIN 24 101 Cytochrome b5 heme-binding.
 MOTIF 186 190 Histidine box-1.
 MOTIF 223 227 Histidine box-2.
 MOTIF 387 391 Histidine box-3.  
Keyword
 Complete proteome; Electron transport; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 449 AA 
Protein Sequence
MGGVGEPGGG PGPREGPAPL GAPLPIFRWE QIRQHDLPGD KWLVIERRVY DISRWAQRHP 60
GGSRLIGHHG AEDATDAFHA FHQDLHFVRK FLKPLLIGEL APEEPSQDGA QNAQLIEDFR 120
ALRQAAEDMK LFEADTTFFA LLLGHILAME LLAWLIIYLL GPGWVSSILA ALILAISQAQ 180
CWCLQHDLGH ASIFTKSRWN HVAQQFVMGQ LKGFSAHWWN FRHFQHHAKP NIFHKDPDVT 240
VAPVFLLGES SVEYGKKKRR YLPYNHQHLY FFLIGPPLLT LVNFEVENLA YMLVCMQWTD 300
LLWAASFYSR FFLSYSPFYG ATGTLLLFVA VRVLESHWFV WITQMNHIPK EIGHEKHRDW 360
ASSQLAATCN VEPSLFIDWF SGHLNFQIEH HLFPTMPRHN YRRVAPLVKA FCAKHGLHYE 420
VKPFLTALVD IIGSLKKSGD IWLDAYLHQ 449 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR001199; Cyt_B5-like_heme/steroid-bd.
 IPR012171; Fatty_acid/sphinglp_desaturase.
 IPR005804; Fatty_acid_desaturase-1. 
Pfam
 PF00173; Cyt-b5
 PF00487; FA_desaturase 
SMART
  
PROSITE
 PS00191; CYTOCHROME_B5_1
 PS50255; CYTOCHROME_B5_2 
PRINTS