| Tag | Content |
|---|
| CPLM ID | CPLM-004010 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial brown fat uncoupling protein 1 |
Protein Synonyms/Alias | UCP 1; Solute carrier family 25 member 7; Thermogenin |
Gene Name | Ucp1 |
Gene Synonyms/Alias | Slc25a7; Ucp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 199 | LVTYDLMKGALVNNK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. |
Sequence Annotation | REPEAT 11 102 Solcar 1.
REPEAT 111 201 Solcar 2.
REPEAT 210 295 Solcar 3.
REGION 274 296 Purine nucleotide binding (By |
Keyword | Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 307 AA |
Protein Sequence | MVNPTTSEVQ PTMGVKIFSA GVSACLADII TFPLDTAKVR LQIQGEGQAS STIRYKGVLG 60
TITTLAKTEG LPKLYSGLPA GIQRQISFAS LRIGLYDSVQ EYFSSGRETP ASLGNKISAG 120
LMTGGVAVFI GQPTEVVKVR MQAQSHLHGI KPRYTGTYNA YRVIATTESL STLWKGTTPN 180
LMRNVIINCT ELVTYDLMKG ALVNNKILAD DVPCHLLSAL VAGFCTTLLA SPVDVVKTRF 240
INSLPGQYPS VPSCAMSMYT KEGPTAFFKG FVASFLRLGS WNVIMFVCFE QLKKELMKSR 300
QTVDCTT 307 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005740; C:mitochondrial envelope; IDA:MGI. GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. GO:0017077; F:oxidative phosphorylation uncoupler activity; IDA:MGI. GO:0050873; P:brown fat cell differentiation; IEP:HGNC. GO:0006839; P:mitochondrial transport; IEA:InterPro. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |