UniProt Accession

 RIT2_HUMAN; Q99578; B2R9L1; O15295; Q8TD69; Q8WVF6; Q92964 

Genbank Protein ID

 U71204; Y07565; U78164; U78166; AF493922; AY563951; AK313823; CH471088; BC018060 

Genbank Nucleotide ID

 AAB42214.1; CAA68850.1; AAB64245.1; AAB64247.1; AAM12636.1; AAS75332.1; BAG36558.1; EAX01432.1; AAH18060.1 

Protein Name

 GTP-binding protein Rit2 

Protein Synonyms/Alias

 Ras-like protein expressed in neurons; Ras-like without CAAX protein 2 

Gene Name

 RIT2 

Gene Synonyms/Alias

 RIN; ROC2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	SGGSREYKVVMLGAG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Binds and exchanges GTP and GDP (By similarity). 

Sequence Annotation

 NP_BIND 27 34 GTP (By similarity).
 NP_BIND 74 78 GTP (By similarity).
 NP_BIND 133 136 GTP (By similarity).  

Keyword

 Alternative splicing; Calmodulin-binding; Cell membrane; Complete proteome; GTP-binding; Membrane; Nucleotide-binding; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:UniProtKB.
 GO:0005516; F:calmodulin binding; TAS:ProtInc.
 GO:0005525; F:GTP binding; TAS:ProtInc.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.
 GO:0007268; P:synaptic transmission; TAS:ProtInc. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 

Pfam

 PF00071; Ras 

SMART

 SM00173; RAS 

PROSITE

 PS51421; RAS 

PRINTS

 PR00449; RASTRNSFRMNG.