UniProt Accession

 TCP4_DROME; Q9VLR5; Q24026; Q4V3U5 

Genbank Protein ID

 U18971; AE014134; BT023261 

Genbank Nucleotide ID

 AAC46989.1; AAF52619.1; AAY55677.1 

Protein Name

 RNA polymerase II transcriptional coactivator 

Protein Synonyms/Alias

 p11 

Gene Name

 Ssb-c31a 

Gene Synonyms/Alias

 CG8396 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
76	DIREFYDKGGQILPG	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity). Binds specifically to the NssBF element, a short nucleotide sequence of the 1731 retrotransposon, to repress promoter activity. 

Sequence Annotation

  

Keyword

 Activator; Complete proteome; DNA-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0003697; F:single-stranded DNA binding; IDA:FlyBase.
 GO:0003713; F:transcription coactivator activity; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003173; PC4.
 IPR009044; ssDNA-bd_transcriptional_reg. 

Pfam

 PF02229; PC4 

SMART

  

PROSITE

  

PRINTS