UniProt Accession

 KRA58_HUMAN; O75690; Q6L8G7; Q6UTX6 

Genbank Protein ID

 AJ006692; AB126077; AY360461 

Genbank Nucleotide ID

 CAA07188.1; BAD20204.1; AAQ62965.1 

Protein Name

 Keratin-associated protein 5-8 

Protein Synonyms/Alias

 Keratin, ultra high-sulfur matrix protein B; Keratin-associated protein 5.8; UHS keratin B; UHS KerB; Ultrahigh sulfur keratin-associated protein 5.8 

Gene Name

 KRTAP5-8 

Gene Synonyms/Alias

 KAP5.8; KRTAP5.8; UHSKB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
111	CCQSSCCKPCCSQSS	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. 

Sequence Annotation

 REPEAT 28 31 1.
 REPEAT 34 37 2.
 REPEAT 40 43 3.
 REPEAT 109 112 4.
 REPEAT 119 122 5.
 REPEAT 138 141 6.
 REPEAT 148 151 7.
 REPEAT 167 170 8.
 REPEAT 177 180 9.
 REGION 28 180 9 X 4 AA repeats of C-C-X-P.  

Keyword

 Complete proteome; Keratin; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 187 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0030280; F:structural constituent of epidermis; NAS:UniProtKB. 

Interpro

 IPR002494; Keratin-assoc. 

Pfam

  

SMART

  

PROSITE

  

PRINTS