CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002221
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Steroid 17-alpha-hydroxylase/17,20 lyase 
Protein Synonyms/Alias
 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase 
Gene Name
 CYP17A1 
Gene Synonyms/Alias
 CYP17; S17AH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
326LHNPQVKKKLYEEIDacetylation[1]
327HNPQVKKKLYEEIDQacetylation[1]
Reference
 [1] The interaction of cytochrome P450 17alpha with NADPH-cytochrome P450 reductase, investigated using chemical modification and MALDI-TOF mass spectrometry.
 Nikfarjam L, Izumi S, Yamazaki T, Kominami S.
 Biochim Biophys Acta. 2006 Jun;1764(6):1126-31. [PMID: 16713412] 
Functional Description
 Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. 
Sequence Annotation
 METAL 442 442 Iron (heme axial ligand).  
Keyword
 3D-structure; Complete proteome; Congenital adrenal hyperplasia; Disease mutation; Heme; Iron; Lyase; Membrane; Metal-binding; Monooxygenase; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Steroidogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 508 AA 
Protein Sequence
MWELVALLLL TLAYLFWPKR RCPGAKYPKS LLSLPLVGSL PFLPRHGHMH NNFFKLQKKY 60
GPIYSVRMGT KTTVIVGHHQ LAKEVLIKKG KDFSGRPQMA TLDIASNNRK GIAFADSGAH 120
WQLHRRLAMA TFALFKDGDQ KLEKIICQEI STLCDMLATH NGQSIDISFP VFVAVTNVIS 180
LICFNTSYKN GDPELNVIQN YNEGIIDNLS KDSLVDLVPW LKIFPNKTLE KLKSHVKIRN 240
DLLNKILENY KEKFRSDSIT NMLDTLMQAK MNSDNGNAGP DQDSELLSDN HILTTIGDIF 300
GAGVETTTSV VKWTLAFLLH NPQVKKKLYE EIDQNVGFSR TPTISDRNRL LLLEATIREV 360
LRLRPVAPML IPHKANVDSS IGEFAVDKGT EVIINLWALH HNEKEWHQPD QFMPERFLNP 420
AGTQLISPSV SYLPFGAGPR SCIGEILARQ ELFLIMAWLL QRFDLEVPDD GQLPSLEGIP 480
KVVFLIDSFK VKIKVRQAWR EAQAEGST 508 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0047442; F:17-alpha-hydroxyprogesterone aldolase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IDA:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; TAS:ProtInc.
 GO:0004508; F:steroid 17-alpha-monooxygenase activity; IDA:UniProtKB.
 GO:0030325; P:adrenal gland development; IEA:Compara.
 GO:0006702; P:androgen biosynthetic process; TAS:Reactome.
 GO:0018879; P:biphenyl metabolic process; IEA:Compara.
 GO:0071236; P:cellular response to antibiotic; IEA:Compara.
 GO:0071371; P:cellular response to gonadotropin stimulus; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0018894; P:dibenzo-p-dioxin metabolic process; IEA:Compara.
 GO:0006704; P:glucocorticoid biosynthetic process; TAS:Reactome.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0033327; P:Leydig cell differentiation; IEA:Compara.
 GO:0030728; P:ovulation; IEA:Compara.
 GO:0018958; P:phenol-containing compound metabolic process; IEA:Compara.
 GO:0018963; P:phthalate metabolic process; IEA:Compara.
 GO:0090031; P:positive regulation of steroid hormone biosynthetic process; IEA:Compara.
 GO:0042448; P:progesterone metabolic process; IDA:UniProtKB.
 GO:0010034; P:response to acetate; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0060992; P:response to fungicide; IEA:Compara.
 GO:0009635; P:response to herbicide; IEA:Compara.
 GO:0017085; P:response to insecticide; IEA:Compara.
 GO:0010212; P:response to ionizing radiation; IEA:Compara.
 GO:0051597; P:response to methylmercury; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0048545; P:response to steroid hormone stimulus; IEA:Compara.
 GO:0007548; P:sex differentiation; TAS:ProtInc.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.