UniProt Accession

 B4DFA2_HUMAN; B4DFA2 

Genbank Protein ID

 AC138645; AC217780; AK294001 

Genbank Nucleotide ID

 BAG57363.1 

Protein Name

 Vesicle-fusing ATPase 

Protein Synonyms/Alias

 cDNA FLJ59316, highly similar to Vesicle-fusing ATPase (EC 3.6.4.6) 

Gene Name

 NSF 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
172	YGPPGCGKTLLARQI	ubiquitination	[1]
181	LLARQIGKMLNAREP	ubiquitination	[1]
368	RHIKASTKVEVDMEK	ubiquitination	[2]
435	ELLVQQTKNSDRTPL	ubiquitination	[1, 3]
461	GKTALAAKIAEESNF	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 644 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042623; F:ATPase activity, coupled; IEA:Compara.
 GO:0006813; P:potassium ion transport; IEA:Compara. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR004201; Cdc48_dom2.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA
 PF02933; CDC48_2 

SMART

 SM00382; AAA
 SM01072; CDC48_2 

PROSITE

 PS00674; AAA 

PRINTS