UniProt Accession

 B7Z7A3_HUMAN; B7Z7A3 

Genbank Protein ID

 AC022536; AL359878; AK301721 

Genbank Nucleotide ID

 BAH13539.1 

Protein Name

 Nucleolar GTP-binding protein 1 

Protein Synonyms/Alias

  

Gene Name

 GTPBP4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	LGQINIAKNLVDNVA	ubiquitination	[1, 2, 3]
64	NLVDNVAKDYVRLMK	ubiquitination	[2, 3]
71	KDYVRLMKYGDSLYR	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the biogenesis of the 60S ribosomal subunit (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 587 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. 

Interpro

 IPR006073; GTP_binding_domain.
 IPR024926; NOG1.
 IPR010674; NOG1_Rossman_fold_dom.
 IPR012973; NOG_C.
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom. 

Pfam

 PF06858; NOG1
 PF08155; NOGCT 

SMART

  

PROSITE

  

PRINTS

 PR00326; GTP1OBG.