UniProt Accession

 TUSC3_HUMAN; Q13454; A8MSM0; D3DSP2; Q14911; Q14912; Q96FW0 

Genbank Protein ID

 U42349; U42359; U42350; U42351; U42352; U42354; U42355; U42356; U42357; U42358; U42360; U42350; U42351; U42352; U42354; U42355; U42356; U42357; U42358; BT020002; AC010656; AC019292; AC091559; AC100850; CH471080; CH471080; BC010370 

Genbank Nucleotide ID

 AAB18374.1; AAB18375.1; AAB18375.1; AAB18375.1; AAB18375.1; AAB18375.1; AAB18375.1; AAB18375.1; AAB18375.1; AAB18375.1; AAB18376.1; AAB18376.1; AAB18376.1; AAB18376.1; AAB18376.1; AAB18376.1; AAB18376.1; AAB18376.1; AAB18376.1; AAV38805.1; EAW63837.1; EAW63839.1; AAH10370.1 

Protein Name

 Tumor suppressor candidate 3 

Protein Synonyms/Alias

 Magnesium uptake/transporter TUSC3; Protein N33 

Gene Name

 TUSC3 

Gene Synonyms/Alias

 N33 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
180	FAAEQLAKWIADRTD	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Magnesium transporter. May be involved in N- glycosylation through its association with N-oligosaccharyl transferase. 

Sequence Annotation

 DOMAIN 59 187 Thioredoxin.
 DISULFID 99 102 Redox-active (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Disulfide bond; Endoplasmic reticulum; Magnesium; Membrane; Mental retardation; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 348 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0008250; C:oligosaccharyltransferase complex; IDA:HGNC.
 GO:0015095; F:magnesium ion transmembrane transporter activity; IMP:UniProtKB.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0050890; P:cognition; IMP:UniProtKB.
 GO:0015693; P:magnesium ion transport; IGI:UniProtKB.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; ISS:UniProtKB. 

Interpro

 IPR006844; Mg_transporter-1.
 IPR021149; OligosaccharylTrfase_OST3/OST6.
 IPR012336; Thioredoxin-like_fold.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF04756; OST3_OST6
 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS