CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017988
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methyltransferase-like protein 6 
Protein Synonyms/Alias
  
Gene Name
 METTL6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
120PRAIEYVKQNPLYDTubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Probable methyltransferase (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 284 AA 
Protein Sequence
MASLQRKGLQ ARILTSEEEE KLKRDQTLVS DFKQQKLEQE AQKNWDLFYK RNSTNFFKDR 60
HWTTREFEEL RSCREFEDQK LTMLEAGCGV GNCLFPLLEE DPNIFAYACD FSPRAIEYVK 120
QNPLYDTERC KVFQCDLTKD DLLDHVPPES VDVVMLIFVL SAVHPDKMHL VLQNIYKVLK 180
PGKSVLFRDY GLYDHAMLRF KASSKLGENF YVRQDGTRSY FFTDDFLAQL FMDTGYEEVV 240
NEYVFRETVN KKEGLCVPRV FLQSKFLKPP KNPSPVVLGL DPKS 284 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. 
Interpro
 IPR013217; Methyltransf_12.
 IPR026113; MeTrfase. 
Pfam
 PF08242; Methyltransf_12 
SMART
  
PROSITE
  
PRINTS