CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002751
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribonuclease D 
Protein Synonyms/Alias
 RNase D 
Gene Name
 rnd 
Gene Synonyms/Alias
 b1804; JW1793 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
273SEIRFHGKTLLALVEacetylation[1]
308PGYRKAFKAIKSLITacetylation[1]
311RKAFKAIKSLITDVSacetylation[1]
343QLLNWHWKLKPQNNLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides. 
Sequence Annotation
 DOMAIN 3 169 3'-5' exonuclease.
 DOMAIN 210 289 HRDC.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Exonuclease; Hydrolase; Nuclease; Reference proteome; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MNYQMITTDD ALASLCEAVR AFPAIALDTE FVRTRTYYPQ LGLIQLFDGE HLALIDPLGI 60
TDWSPLKAIL RDPSITKFLH AGSEDLEVFL NVFGELPQPL IDTQILAAFC GRPMSWGFAS 120
MVEEYSGVTL DKSESRTDWL ARPLTERQCE YAAADVWYLL PITAKLMVET EASGWLPAAL 180
DECRLMQMRR QEVVAPEDAW RDITNAWQLR TRQLACLQLL ADWRLRKARE RDLAVNFVVR 240
EEHLWSVARY MPGSLGELDS LGLSGSEIRF HGKTLLALVE KAQTLPEDAL PQPMLNLMDM 300
PGYRKAFKAI KSLITDVSET HKISAELLAS RRQINQLLNW HWKLKPQNNL PELISGWRGE 360
LMAEALHNLL QEYPQ 375 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0004540; F:ribonuclease activity; IMP:EcoCyc.
 GO:0033890; F:ribonuclease D activity; IEA:HAMAP.
 GO:0042780; P:tRNA 3'-end processing; IEA:HAMAP.
 GO:0008033; P:tRNA processing; IMP:EcoCyc. 
Interpro
 IPR002562; 3'-5'_exonuclease_dom.
 IPR010997; HRDC-like.
 IPR002121; HRDC_dom.
 IPR006292; RNase_D.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF01612; DNA_pol_A_exo1
 PF00570; HRDC 
SMART
 SM00474; 35EXOc
 SM00341; HRDC 
PROSITE
 PS50967; HRDC 
PRINTS