CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005476
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin alpha-3 
Protein Synonyms/Alias
 CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD49c; Integrin alpha-3 heavy chain; Integrin alpha-3 light chain 
Gene Name
 ITGA3 
Gene Synonyms/Alias
 MSK18 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43DTRFLVVKEAGNPGSubiquitination[1]
161DQRRMVGKCYVRGNDubiquitination[2]
407YIYHSSSKGLLRQPQubiquitination[3]
471PVINIVHKTLVPRPAubiquitination[1, 3]
638FVSEQQQKLSRLQYSubiquitination[1, 4]
894PVTLAAAKKAKSETVubiquitination[1, 4]
1031TRALYEAKRQKAEMKubiquitination[2]
1038KRQKAEMKSQPSETEubiquitination[1, 4, 5]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. 
Sequence Annotation
 REPEAT 38 103 FG-GAP 1.
 REPEAT 110 171 FG-GAP 2.
 REPEAT 185 236 FG-GAP 3.
 REPEAT 237 293 FG-GAP 4.
 REPEAT 294 354 FG-GAP 5.
 REPEAT 356 411 FG-GAP 6.
 REPEAT 415 477 FG-GAP 7.
 REGION 1015 1021 Interaction with HPS5.
 MOTIF 1017 1021 GFFKR motif.
 CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
 CARBOHYD 107 107 N-linked (GlcNAc...) (Potential).
 CARBOHYD 265 265 N-linked (GlcNAc...) (Potential).
 CARBOHYD 500 500 N-linked (GlcNAc...) (Potential).
 CARBOHYD 511 511 N-linked (GlcNAc...) (Potential).
 CARBOHYD 573 573 N-linked (GlcNAc...) (Potential).
 CARBOHYD 605 605 N-linked (GlcNAc...) (Potential).
 CARBOHYD 656 656 N-linked (GlcNAc...) (Potential).
 CARBOHYD 697 697 N-linked (GlcNAc...) (Potential).
 CARBOHYD 841 841 N-linked (GlcNAc...) (Potential).
 CARBOHYD 857 857 N-linked (GlcNAc...) (Potential).
 CARBOHYD 926 926 N-linked (GlcNAc...) (Potential).
 CARBOHYD 935 935 N-linked (GlcNAc...) (Potential).
 CARBOHYD 969 969 N-linked (GlcNAc...) (Potential).
 DISULFID 94 103
 DISULFID 140 162
 DISULFID 185 197
 DISULFID 485 490 By similarity.
 DISULFID 496 550 By similarity.
 DISULFID 615 621
 DISULFID 694 702
 DISULFID 846 904 Interchain (between heavy and light
 DISULFID 911 916  
Keyword
 Alternative splicing; Calcium; Cell adhesion; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Epidermolysis bullosa; Glycoprotein; Integrin; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1051 AA 
Protein Sequence
MGPGPSRAPR APRLMLCALA LMVAAGGCVV SAFNLDTRFL VVKEAGNPGS LFGYSVALHR 60
QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE 120
DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY 180
HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK 240
DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG 300
SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL 360
LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE 420
KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL 480
DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH 540
GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA 600
QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT 660
RTSERSGEDA HEALLTLVVP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF 720
EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM 780
GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG 840
NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET 900
VLTCATGRAH CVWLECPIPD APVVTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT 960
SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCGFFK 1020
RARTRALYEA KRQKAEMKSQ PSETERLTDD Y 1051 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0008305; C:integrin complex; TAS:ProtInc.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0007613; P:memory; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara. 
Interpro
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS. 
Pfam
 PF08441; Integrin_alpha2 
SMART
 SM00191; Int_alpha 
PROSITE
 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA 
PRINTS
 PR01185; INTEGRINA.