UniProt Accession

 YRA1_YEAST; Q12159; D6VT14 

Genbank Protein ID

 U72633; U28373; U32274; BK006938 

Genbank Nucleotide ID

 AAC09951.1; AAB64817.1; AAB64823.1; DAA12224.1 

Protein Name

 RNA annealing protein YRA1 

Protein Synonyms/Alias

  

Gene Name

 YRA1 

Gene Synonyms/Alias

 YDR381W; D9481.2; D9509.1 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
17	DEIIGSNKAGSNRAR	acetylation	[1]
70	NAVARVAKLLDTTRE	acetylation	[1]
70	NAVARVAKLLDTTRE	ubiquitination	[2]
165	DPNQRPVKSLADRIK	acetylation	[1]
210	KREKPAKKSLEDLDK	acetylation	[1]
217	KSLEDLDKEMADYFE	acetylation	[1]
225	EMADYFEKK******	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 RNA-binding RNA annealing protein. May have a role in pre-mRNA metabolism. Component the TREX complex, which operates in coupling transcription elongation to mRNA export. 

Sequence Annotation

 DOMAIN 78 158 RRM.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 8 8 Phosphoserine.
 MOD_RES 100 100 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0000346; C:transcription export complex; IPI:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IDA:SGD.
 GO:0006406; P:mRNA export from nucleus; IGI:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; IMP:SGD. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS