UniProt Accession

 THIKA_MOUSE; Q921H8 

Genbank Protein ID

 AY273811; AY304542; BC012400 

Genbank Nucleotide ID

 AAP31668.1; AAP72964.1; AAH12400.1 

Protein Name

 3-ketoacyl-CoA thiolase A, peroxisomal 

Protein Synonyms/Alias

 Acetyl-CoA acyltransferase A; Beta-ketothiolase A; Peroxisomal 3-oxoacyl-CoA thiolase A 

Gene Name

 Acaa1a 

Gene Synonyms/Alias

 Acaa1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
79	VLQDVRLKPEQLGDI	ubiquitination	[1]
173	SRLLESEKARDCLTP	acetylation	[2]
198	RFGISRQKQDDFALA	acetylation	[2]
198	RFGISRQKQDDFALA	ubiquitination	[1]
209	FALASQQKAASAQSR	ubiquitination	[1]
234	TTTVLDDKGDKKTIT	acetylation	[2]
237	VLDDKGDKKTITVSQ	acetylation	[2]
237	VLDDKGDKKTITVSQ	ubiquitination	[1]
259	TTMQGLAKLKPAFKD	acetylation	[2]
265	AKLKPAFKDGGSTTA	acetylation	[2]
292	VLLARRSKAEELGLP	acetylation	[2]
395	VTLLNELKRRGRRAY	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

  

Sequence Annotation

 ACT_SITE 123 123 Acyl-thioester intermediate (By
 ACT_SITE 377 377 Proton acceptor (By similarity).
 ACT_SITE 408 408 Proton acceptor (By similarity).  

Keyword

 Acyltransferase; Complete proteome; Fatty acid metabolism; Lipid metabolism; Peroxisome; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 424 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; IDA:UniProtKB.
 GO:0003985; F:acetyl-CoA C-acetyltransferase activity; TAS:MGI.
 GO:0006631; P:fatty acid metabolic process; TAS:MGI. 

Interpro

 IPR002155; Thiolase.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr.
 IPR020615; Thiolase_acyl_enz_int_AS.
 IPR020610; Thiolase_AS.
 IPR020617; Thiolase_C.
 IPR020613; Thiolase_CS.
 IPR020616; Thiolase_N. 

Pfam

 PF02803; Thiolase_C
 PF00108; Thiolase_N 

SMART

  

PROSITE

 PS00098; THIOLASE_1
 PS00737; THIOLASE_2
 PS00099; THIOLASE_3 

PRINTS