CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005027
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Antigen peptide transporter 1 
Protein Synonyms/Alias
 APT1; ATP-binding cassette sub-family B member 2; Histocompatibility antigen modifier 1; Peptide transporter TAP1 
Gene Name
 Tap1 
Gene Synonyms/Alias
 Abcb2; Ham-1; Ham1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
254QETGFFLKNPAGSITubiquitination[1]
365NEEGEAQKFRQKLEEubiquitination[1]
453KAVGSSEKIFEYLDRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity). 
Sequence Annotation
 DOMAIN 163 446 ABC transmembrane type-1.
 DOMAIN 479 718 ABC transporter.
 NP_BIND 514 521 ATP (Potential).
 REGION 351 396 Involved in peptide-binding site (By
 REGION 429 463 Involved in peptide-binding site (By  
Keyword
 Adaptive immunity; ATP-binding; Complete proteome; Endoplasmic reticulum; Immunity; Membrane; Nucleotide-binding; Peptide transport; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 724 AA 
Protein Sequence
MAAHVWLAAA LLLLVDWLLL RPMLPGIFSL LVPEVPLLRV WVVGLSRWAI LGLGVRGVLG 60
VTAGAHGWLA ALQPLVAALS LALPGLALFR ELAAWGTLRE GDSAGLLYWN SRPDAFAISY 120
VAALPAAALW HKLGSLWAPS GNRDAGDMLC RMLGFLGPKK RRLYLVLVLL ILSCLGEMAI 180
PFFTGRITDW ILQDKTVPSF TRNIWLMSIL TIASTALEFA SDGIYNITMG HMHGRVHREV 240
FRAVLRQETG FFLKNPAGSI TSRVTEDTAN VCESISGTLS LLLWYLGRAL CLLVFMFWGS 300
PYLTLVTLIN LPLLFLLPKK LGKVHQSLAV KVQESLAKST QVALEALSAM PTVRSFANEE 360
GEAQKFRQKL EEMKTLNKKE ALAYVAEVWT TSVSGMLLKV GILYLGGQLV IRGAVSSGNL 420
VSFVLYQLQF TQAVQVLLSL YPSMQKAVGS SEKIFEYLDR TPCSPLSGSL APSNMKGLVE 480
FQDVSFAYPN QPKVQVLQGL TFTLHPGTVT ALVGPNGSGK STVAALLQNL YQPTGGQLLL 540
DGQCLVQYDH HYLHTQVAAV GQEPLLFGRS FRENIAYGLN RTPTMEEITA VAVESGAHDF 600
ISGFPQGYDT EVGETGNQLS GGQRQAVALA RALIRKPLLL ILDDATSALD AGNQLRVQRL 660
LYESPKRASR TVLLITQQLS LAEQAHHILF LREGSVGEQG THLQLMKRGG CYRAMVEALA 720
APAD 724 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0042825; C:TAP complex; IBA:RefGenome.
 GO:0043531; F:ADP binding; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0015421; F:oligopeptide-transporting ATPase activity; IBA:RefGenome.
 GO:0042605; F:peptide antigen binding; IBA:RefGenome.
 GO:0046978; F:TAP1 binding; IBA:RefGenome.
 GO:0046979; F:TAP2 binding; IBA:RefGenome.
 GO:0046980; F:tapasin binding; IBA:RefGenome.
 GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Compara.
 GO:0046967; P:cytosol to ER transport; IEA:Compara.
 GO:0006952; P:defense response; IMP:MGI.
 GO:0019060; P:intracellular transport of viral proteins in host cell; IEA:Compara.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IBA:RefGenome. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013305; ABC_B2.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005293; Ag_transporter2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS
 PR01896; TAP1PROTEIN.