UniProt Accession

 GOPC_HUMAN; Q9HD26; A6NM30; Q59FS4; Q969U8 

Genbank Protein ID

 AF287894; AY033606; AF450008; AB209385; AL589939; Z85999; AL589939; Z85999; Z85999; AL589939; Z85999; AL589939; CH471051; BC009553 

Genbank Nucleotide ID

 AAG00572.1; AAK57733.1; AAL47160.1; BAD92622.1; CAH70198.1; CAH70198.1; CAH70199.1; CAH70199.1; CAI43172.1; CAI43172.1; CAI43173.1; CAI43173.1; EAW48205.1; AAH09553.1 

Protein Name

 Golgi-associated PDZ and coiled-coil motif-containing protein 

Protein Synonyms/Alias

 CFTR-associated ligand; Fused in glioblastoma; PDZ protein interacting specifically with TC10; PIST 

Gene Name

 GOPC 

Gene Synonyms/Alias

 CAL; FIG 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	SVSQINHKLEAQLVD	acetylation	[1]
102	EAQLVDLKSELTETQ	ubiquitination	[2]
147	SADSGTIKAKLSGPS	ubiquitination	[2]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. 

Sequence Annotation

 DOMAIN 288 371 PDZ.  

Keyword

 3D-structure; Alternative splicing; Cell junction; Cell membrane; Cell projection; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Golgi apparatus; Membrane; Postsynaptic cell membrane; Protein transport; Reference proteome; Synapse; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 462 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; NAS:UniProtKB.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0043234; C:protein complex; IDA:MGI.
 GO:0030140; C:trans-Golgi network transport vesicle; IDA:UniProtKB.
 GO:0005083; F:small GTPase regulator activity; IEA:Compara.
 GO:0045176; P:apical protein localization; NAS:UniProtKB.
 GO:0043004; P:cytoplasmic sequestering of CFTR protein; NAS:UniProtKB.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; NAS:UniProtKB.
 GO:0006893; P:Golgi to plasma membrane transport; NAS:UniProtKB.
 GO:0051260; P:protein homooligomerization; IPI:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007289; P:spermatid nucleus differentiation; IEA:Compara. 

Interpro

 IPR001478; PDZ. 

Pfam

 PF00595; PDZ 

SMART

 SM00228; PDZ 

PROSITE

 PS50106; PDZ 

PRINTS