| Tag | Content |
|---|
| CPLM ID | CPLM-015922 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myosin-14 |
Protein Synonyms/Alias | Myosin heavy chain 14; Myosin heavy chain, non-muscle IIc; Non-muscle myosin heavy chain IIc; NMHC II-C |
Gene Name | MYH14 |
Gene Synonyms/Alias | KIAA2034; FP17425 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 755 | LTPNAIPKGFMDGKQ | ubiquitination | [1] | | 859 | WRLFTKVKPLLQVTR | ubiquitination | [1] | | 880 | ARAQELQKVQELQQQ | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (By similarity). |
Sequence Annotation | DOMAIN 17 802 Myosin head-like.
DOMAIN 803 832 IQ.
NP_BIND 198 205 ATP (Potential).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 1462 1462 Phosphothreonine (By similarity).
MOD_RES 1969 1969 Phosphoserine.
MOD_RES 1989 1989 Phosphoserine. |
Keyword | 3D-structure; Acetylation; Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding; Cell shape; Coiled coil; Complete proteome; Deafness; Direct protein sequencing; Disease mutation; Motor protein; Myosin; Neuropathy; Non-syndromic deafness; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1995 AA |
Protein Sequence | MAAVTMSVPG RKAPPRPGPV PEAAQPFLFT PRGPSAGGGP GSGTSPQVEW TARRLVWVPS 60
ELHGFEAAAL RDEGEEEAEV ELAESGRRLR LPRDQIQRMN PPKFSKAEDM AELTCLNEAS 120
VLHNLRERYY SGLIYTYSGL FCVVINPYKQ LPIYTEAIVE MYRGKKRHEV PPHVYAVTEG 180
AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAHVAS SPKGRKEPGV PGELERQLLQ 240
ANPILEAFGN AKTVKNDNSS RFGKFIRINF DVAGYIVGAN IETYLLEKSR AIRQAKDECS 300
FHIFYQLLGG AGEQLKADLL LEPCSHYRFL TNGPSSSPGQ ERELFQETLE SLRVLGFSHE 360
EIISMLRMVS AVLQFGNIAL KRERNTDQAT MPDNTAAQKL CRLLGLGVTD FSRALLTPRI 420
KVGRDYVQKA QTKEQADFAL EALAKATYER LFRWLVLRLN RALDRSPRQG ASFLGILDIA 480
GFEIFQLNSF EQLCINYTNE KLQQLFNHTM FVLEQEEYQR EGIPWTFLDF GLDLQPCIDL 540
IERPANPPGL LALLDEECWF PKATDKSFVE KVAQEQGGHP KFQRPRHLRD QADFSVLHYA 600
GKVDYKANEW LMKNMDPLND NVAALLHQST DRLTAEIWKD VEGIVGLEQV SSLGDGPPGG 660
RPRRGMFRTV GQLYKESLSR LMATLSNTNP SFVRCIVPNH EKRAGKLEPR LVLDQLRCNG 720
VLEGIRICRQ GFPNRILFQE FRQRYEILTP NAIPKGFMDG KQACEKMIQA LELDPNLYRV 780
GQSKIFFRAG VLAQLEEERD LKVTDIIVSF QAAARGYLAR RAFQKRQQQQ SALRVMQRNC 840
AAYLKLRHWQ WWRLFTKVKP LLQVTRQDEV LQARAQELQK VQELQQQSAR EVGELQGRVA 900
QLEEERARLA EQLRAEAELC AEAEETRGRL AARKQELELV VSELEARVGE EEECSRQMQT 960
EKKRLQQHIQ ELEAHLEAEE GARQKLQLEK VTTEAKMKKF EEDLLLLEDQ NSKLSKERKL 1020
LEDRLAEFSS QAAEEEEKVK SLNKLRLKYE ATIADMEDRL RKEEKGRQEL EKLKRRLDGE 1080
SSELQEQMVE QQQRAEELRA QLGRKEEELQ AALARAEDEG GARAQLLKSL REAQAALAEA 1140
QEDLESERVA RTKAEKQRRD LGEELEALRG ELEDTLDSTN AQQELRSKRE QEVTELKKTL 1200
EEETRIHEAA VQELRQRHGQ ALGELAEQLE QARRGKGAWE KTRLALEAEV SELRAELSSL 1260
QTARQEGEQR RRRLELQLQE VQGRAGDGER ARAEAAEKLQ RAQAELENVS GALNEAESKT 1320
IRLSKELSST EAQLHDAQEL LQEETRAKLA LGSRVRAMEA EAAGLREQLE EEAAARERAG 1380
RELQTAQAQL SEWRRRQEEE AGALEAGEEA RRRAAREAEA LTQRLAEKTE TVDRLERGRR 1440
RLQQELDDAT MDLEQQRQLV STLEKKQRKF DQLLAEEKAA VLRAVEERER AEAEGREREA 1500
RALSLTRALE EEQEAREELE RQNRALRAEL EALLSSKDDV GKSVHELERA CRVAEQAAND 1560
LRAQVTELED ELTAAEDAKL RLEVTVQALK TQHERDLQGR DEAGEERRRQ LAKQLRDAEV 1620
ERDEERKQRT LAVAARKKLE GELEELKAQM ASAGQGKEEA VKQLRKMQAQ MKELWREVEE 1680
TRTSREEIFS QNRESEKRLK GLEAEVLRLQ EELAASDRAR RQAQQDRDEM ADEVANGNLS 1740
KAAILEEKRQ LEGRLGQLEE ELEEEQSNSE LLNDRYRKLL LQVESLTTEL SAERSFSAKA 1800
ESGRQQLERQ IQELRGRLGE EDAGARARHK MTIAALESKL AQAEEQLEQE TRERILSGKL 1860
VRRAEKRLKE VVLQVEEERR VADQLRDQLE KGNLRVKQLK RQLEEAEEEA SRAQAGRRRL 1920
QRELEDVTES AESMNREVTT LRNRLRRGPL TFTTRTVRQV FRLEEGVASD EEAEEAQPGS 1980
GPSPEPEGSP PAHPQ 1995 |
Gene Ontology | |
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PROSITE | |
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