UniProt Accession

 NDRG2_MOUSE; Q9QYG0; Q3TI48; Q3TY42; Q3U3T5; Q69ZN2; Q8C661 

Genbank Protein ID

 AB033921; AK076514; AK154597; AK158900; AK168011; BC012963; AK173136 

Genbank Nucleotide ID

 BAA85882.1; BAC36373.1; BAE32700.1; BAE34721.1; BAE39998.1; AAH12963.1; BAD32414.1 

Protein Name

 Protein NDRG2 

Protein Synonyms/Alias

 N-myc downstream-regulated gene 2 protein; Protein Ndr2 

Gene Name

 Ndrg2 

Gene Synonyms/Alias

 Kiaa1248; Ndr2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
25	GQTPETAKEAELAAR	ubiquitination	[1]
287	PTQTSFLKMADSGGQ	ubiquitination	[1]
302	PQLTQPGKLTEAFKY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 326 326 Phosphoserine.
 MOD_RES 328 328 Phosphoserine.
 MOD_RES 330 330 Phosphothreonine; by SGK1.
 MOD_RES 332 332 Phosphoserine; by PKC/PRKCQ or SGK1.
 MOD_RES 334 334 Phosphothreonine.
 MOD_RES 335 335 Phosphoserine.
 MOD_RES 338 338 Phosphoserine.
 MOD_RES 342 342 Phosphoserine.
 MOD_RES 344 344 Phosphoserine.
 MOD_RES 346 346 Phosphoserine.
 MOD_RES 348 348 Phosphothreonine; by PKB/AKT1 or SGK1.
 MOD_RES 350 350 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 353 353 Phosphoserine.
 MOD_RES 355 355 Phosphoserine.
 MOD_RES 357 357 Phosphothreonine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Neurogenesis; Phosphoprotein; Reference proteome; Tumor suppressor; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0001818; P:negative regulation of cytokine production; IMP:MGI.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:MGI.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IDA:MGI.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0090361; P:regulation of platelet-derived growth factor production; IMP:MGI.
 GO:0010574; P:regulation of vascular endothelial growth factor production; IMP:MGI.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR004142; Ndr. 

Pfam

 PF03096; Ndr 

SMART

  

PROSITE

  

PRINTS