UniProt Accession

 SCOT1_RAT; B2GV06 

Genbank Protein ID

 CH474048; BC166478 

Genbank Nucleotide ID

 EDL75738.1; AAI66478.1 

Protein Name

 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 

Protein Synonyms/Alias

 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s 

Gene Name

 Oxct1 

Gene Synonyms/Alias

 Oxct; Scot 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
41	VSTRHHTKFYTDPVE	acetylation	[1]
83	ALLKTGVKDLTAVSN	acetylation	[1]
176	GSPIKYNKDGSVAIA	acetylation	[1]
185	GSVAIASKPREVREF	acetylation	[1]
214	FALVKAWKADRAGNV	acetylation	[1]
271	IYVHRLIKGEKYEKR	acetylation	[1]
274	HRLIKGEKYEKRIER	acetylation	[1]
296	EGKAKSGKPGEDVRE	acetylation	[1]
418	ANWMIPGKMVKGMGG	acetylation	[1]
421	MIPGKMVKGMGGAMD	acetylation	[1]
451	SAKGNAHKIMEKCTL	acetylation	[1]
455	NAHKIMEKCTLPLTG	acetylation	[1]
473	VNRIITEKGVFDVDK	acetylation	[1]
480	KGVFDVDKKNGLTLI	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). 

Sequence Annotation

 ACT_SITE 344 344 Acyl-thioester intermediate (By
 MOD_RES 170 170 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Mitochondrion; Phosphoprotein; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 520 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0008260; F:3-oxoacid CoA-transferase activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0060612; P:adipose tissue development; IEP:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0046950; P:cellular ketone body metabolic process; IEP:RGD.
 GO:0071229; P:cellular response to acid; IMP:RGD.
 GO:0071333; P:cellular response to glucose stimulus; IMP:RGD.
 GO:0007507; P:heart development; IEP:RGD.
 GO:0046952; P:ketone body catabolic process; IEA:Compara.
 GO:0042182; P:ketone catabolic process; IEA:Compara.
 GO:0032024; P:positive regulation of insulin secretion; IMP:RGD.
 GO:0014823; P:response to activity; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0009725; P:response to hormone stimulus; IEP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0042594; P:response to starvation; IEP:RGD. 

Interpro

 IPR012792; 3-oxoacid_CoA-transf_A.
 IPR012791; 3-oxoacid_CoA-transf_B.
 IPR014388; 3-oxoacid_CoA-transferase.
 IPR004165; CoA_trans_fam_I.
 IPR004164; CoA_transf_AS.
 IPR004163; CoA_transf_BS. 

Pfam

 PF01144; CoA_trans 

SMART

 SM00882; CoA_trans 

PROSITE

 PS01273; COA_TRANSF_1
 PS01274; COA_TRANSF_2 

PRINTS