| Tag | Content |
|---|
| CPLM ID | CPLM-012176 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Apoptosis-stimulating of p53 protein 2 |
Protein Synonyms/Alias | Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2 |
Gene Name | TP53BP2 |
Gene Synonyms/Alias | ASPP2; BBP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 158 | QQQLLATKEQRLKFL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. |
Sequence Annotation | REPEAT 958 990 ANK 1.
REPEAT 991 1023 ANK 2.
DOMAIN 1057 1119 SH3.
REGION 332 348 Interaction with APPBP1.
REGION 876 1128 Mediates interaction with APC2.
MOTIF 866 875 SH3-binding (Potential).
MOD_RES 480 480 Phosphoserine.
MOD_RES 556 556 Phosphoserine.
MOD_RES 572 572 Phosphoserine.
MOD_RES 698 698 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; ANK repeat; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; SH3 domain; SH3-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1128 AA |
Protein Sequence | MRFGSKMMPM FLTVYLSNNE QHFTEVPVTP ETICRDVVDL CKEPGESDCH LAEVWCGSER 60
PVADNERMFD VLQRFGSQRN EVRFFLRHER PPGRDIVSGP RSQDPSLKRN GVKVPGEYRR 120
KENGVNSPRM DLTLAELQEM ASRQQQQIEA QQQLLATKEQ RLKFLKQQDQ RQQQQVAEQE 180
KLKRLKEIAE NQEAKLKKVR ALKGHVEQKR LSNGKLVEEI EQMNNLFQQK QRELVLAVSK 240
VEELTRQLEM LKNGRIDSHH DNQSAVAELD RLYKELQLRN KLNQEQNAKL QQQRECLNKR 300
NSEVAVMDKR VNELRDRLWK KKAALQQKEN LPVSSDGNLP QQAASAPSRV AAVGPYIQSS 360
TMPRMPSRPE LLVKPALPDG SLVIQASEGP MKIQTLPNMR SGAASQTKGS KIHPVGPDWS 420
PSNADLFPSQ GSASVPQSTG NALDQVDDGE VPLREKEKKV RPFSMFDAVD QSNAPPSFGT 480
LRKNQSSEDI LRDAQVANKN VAKVPPPVPT KPKQINLPYF GQTNQPPSDI KPDGSSQQLS 540
TVVPSMGTKP KPAGQQPRVL LSPSIPSVGQ DQTLSPGSKQ ESPPAAAVRP FTPQPSKDTL 600
LPPFRKPQTV AASSIYSMYT QQQAPGKNFQ QAVQSALTKT HTRGPHFSSV YGKPVIAAAQ 660
NQQQHPENIY SNSQGKPGSP EPETEPVSSV QENHENERIP RPLSPTKLLP FLSNPYRNQS 720
DADLEALRKK LSNAPRPLKK RSSITEPEGP NGPNIQKLLY QRTTIAAMET ISVPSYPSKS 780
ASVTASSESP VEIQNPYLHV EPEKEVVSLV PESLSPEDVG NASTENSDMP APSPGLDYEP 840
EGVPDNSPNL QNNPEEPNPE APHVLDVYLE EYPPYPPPPY PSGEPEGPGE DSVSMRPPEI 900
TGQVSLPPGK RTNLRKTGSE RIAHGMRVKF NPLALLLDSS LEGEFDLVQR IIYEVDDPSL 960
PNDEGITALH NAVCAGHTEI VKFLVQFGVN VNAADSDGWT PLHCAASCNN VQVCKFLVES 1020
GAAVFAMTYS DMQTAADKCE EMEEGYTQCS QFLYGVQEKM GIMNKGVIYA LWDYEPQNDD 1080
ELPMKEGDCM TIIHREDEDE IEWWWARLND KEGYVPRNLL GLYPRIKPRQ RSLA 1134 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0007417; P:central nervous system development; IEA:Compara. GO:0009792; P:embryo development ending in birth or egg hatching; IEA:Compara. GO:0007507; P:heart development; IEA:Compara. GO:0006917; P:induction of apoptosis; IDA:UniProtKB. GO:0045786; P:negative regulation of cell cycle; TAS:UniProtKB. GO:0010212; P:response to ionizing radiation; IEA:Compara. GO:0007165; P:signal transduction; TAS:ProtInc. |
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