CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010630
UniProt Accession
Genbank Protein ID
 U59761 
Genbank Nucleotide ID
Protein Name
 Sodium/potassium-transporting ATPase subunit beta-3 
Protein Synonyms/Alias
 Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD298 
Gene Name
 Atp1b3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MTKTEKKSFHQSLAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. 
Sequence Annotation
 REGION 186 278 immunoglobulin-like (By similarity).
 CARBOHYD 124 124 N-linked (GlcNAc...).
 CARBOHYD 197 197 N-linked (GlcNAc...).
 DISULFID 128 144 By similarity.
 DISULFID 154 170 By similarity.
 DISULFID 191 249 By similarity.  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium; Sodium transport; Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 278 AA 
Protein Sequence
MTKTEKKSFH QSLAEWKLFI YNPSSGEFLG RTSKSWGLIL LFYLVFYGFL AALFTFTMWA 60
MLQTLNDEVP KYRDQIPSPG LMVFPKPQTA LEYTFSMSEP QTYKKLVEDL ESFLKPYSVE 120
EQKNLTSCPD GAPFIQHGPD YRACQFPVSL LEECSGVTDA NFGYSKGQPC ILVKMNRIID 180
LIPDGYPQIS CLPKEENATI ATYPEFGVLD LKYFPYYGKK RHVGYRQPLV AVQVKFDSGL 240
NKKEVTVECH IAGTRNLKNK NERDKFLGRV SFKVTARA 278 
Gene Ontology
 GO:0005901; C:caveola; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:Compara.
 GO:0005391; F:sodium:potassium-exchanging ATPase activity; IEA:Compara. 
Interpro
 IPR000402; Na/K_ATPase_sub_beta. 
Pfam
 PF00287; Na_K-ATPase 
SMART
  
PROSITE
 PS00390; ATPASE_NA_K_BETA_1 
PRINTS