CPLM-002793

Genbank Nucleotide ID

Ras-related protein Rab-7a

Protein Synonyms/Alias

Ras-related protein BRL-RAS; Ras-related protein p23

Rattus norvegicus (Rat)

Position	Peptide	Type	References
32	MNQYVNKKFSNQYKA	acetylation	[1]

[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]

Functional Description

Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacteria. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.

NP_BIND 15 22 GTP (By similarity).
NP_BIND 63 67 GTP (By similarity).
NP_BIND 125 128 GTP (By similarity).
MOTIF 37 45 Effector region (By similarity).
MOD_RES 72 72 Phosphoserine (By similarity).
MOD_RES 207 207 Cysteine methyl ester (By similarity).
LIPID 205 205 S-geranylgeranyl cysteine (By
LIPID 207 207 S-geranylgeranyl cysteine (By

3D-structure; Complete proteome; Cytoplasmic vesicle; Endosome; GTP-binding; Lipoprotein; Lysosome; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0097208; C:alveolar lamellar body; IDA:RGD.
GO:0005794; C:Golgi apparatus; IEA:Compara.
GO:0005770; C:late endosome; IDA:RGD.
GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0019003; F:GDP binding; IDA:RGD.
GO:0005525; F:GTP binding; IDA:RGD.
GO:0003924; F:GTPase activity; TAS:RGD.
GO:0045453; P:bone resorption; IMP:RGD.
GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
GO:0008333; P:endosome to lysosome transport; IEA:Compara.
GO:0007174; P:epidermal growth factor catabolic process; IEA:Compara.
GO:0090383; P:phagosome acidification; ISS:UniProtKB.
GO:0090385; P:phagosome-lysosome fusion; ISS:UniProtKB.
GO:0006622; P:protein targeting to lysosome; IEA:Compara.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.

IPR027417; P-loop_NTPase.
IPR005225; Small_GTP-bd_dom.
IPR001806; Small_GTPase.
IPR003579; Small_GTPase_Rab_type.

PR00449; RASTRNSFRMNG.